(3R,4R,5R)-1-benzyl-3,4-dihydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

Base Information

Chemical Name:(3R,4R,5R)-1-benzyl-3,4-dihydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone
CAS No.:113571-54-3
Molecular Formula:C₁₄H₁₉NO₅
Molecular Weight:281.309
Hs Code.:

Synonyms:(3R,4R,5R)-1-benzyl-3,4-dihydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R,5R)-1-benzyl-3,4-dihydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

Chemical Property:

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Technology Process of (3R,4R,5R)-1-benzyl-3,4-dihydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

There total 7 articles about (3R,4R,5R)-1-benzyl-3,4-dihydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 113571-53-2
(S)-1-benzyl-5-methoxymethoxymethyl-2-oxo-3-pyrroline

: 113571-54-3
(3R,4R,5R)-1-benzyl-3,4-dihydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

Guidance literature:: osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone;
DOI:10.1248/cpb.35.2140

Reference yield: 65.0%

: 113571-53-2
(S)-1-benzyl-5-methoxymethoxymethyl-2-oxo-3-pyrroline

: 113571-54-3
(3R,4R,5R)-1-benzyl-3,4-dihydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

: 154815-46-0
(3R,4S,5S)-1-Benzyl-3,4,5-trihydroxy-5-methoxymethoxymethyl-pyrrolidin-2-one

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone; for 13h; Ambient temperature;
DOI:10.1248/cpb.41.1717

Reference yield:

: 94615-12-0
(S)-5-(methoxymethoxy)methyl-2-pyrrolidinone

: 113571-54-3
(3R,4R,5R)-1-benzyl-3,4-dihydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.)THF, DMF, RT, 1 h, 2.) THF, DMF, RT, 15 h

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 40 min, 2.) THF, hexane, -78 deg C, 15 min

3: 84 percent / 30percent H₂O₂ / ethyl acetate / 0.33 h / 15 - 20 °C

4: 65 percent / OsO₄, N-methylmorpholine N-oxide / acetone; H₂O / 13 h / Ambient temperature

With osmium(VIII) oxide; dihydrogen peroxide; sodium hydride; 4-methylmorpholine N-oxide; lithium diisopropyl amide; In water; ethyl acetate; acetone;
DOI:10.1248/cpb.41.1717