(3R,4R,5R)-1-benzyl-4-benzyloxy-3-hydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

Base Information

Chemical Name:(3R,4R,5R)-1-benzyl-4-benzyloxy-3-hydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone
CAS No.:127298-78-6
Molecular Formula:C₂₁H₂₅NO₅
Molecular Weight:371.433
Hs Code.:

Synonyms:(3R,4R,5R)-1-benzyl-4-benzyloxy-3-hydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

Suppliers and Price of (3R,4R,5R)-1-benzyl-4-benzyloxy-3-hydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,4R,5R)-1-benzyl-4-benzyloxy-3-hydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,4R,5R)-1-benzyl-4-benzyloxy-3-hydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

There total 1 articles about (3R,4R,5R)-1-benzyl-4-benzyloxy-3-hydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 113571-54-3
(3R,4R,5R)-1-benzyl-3,4-dihydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

: 127298-69-5
(3R,4R,5R)-1-benzyl-3-benzyloxy-4-hydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

: 127298-78-6
(3R,4R,5R)-1-benzyl-4-benzyloxy-3-hydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

Guidance literature:: With di(n-butyl)tin oxide; cesium fluoride; Yield given. Multistep reaction. Yields of byproduct given; 1.) toluene, heating, 2 h, 2.) 1 h, over P₂O₅, 3.) DMF, room temperature, 2 h;
DOI:10.1248/cpb.37.3399

Reference yield: 94.0%

: 127298-78-6
(3R,4R,5R)-1-benzyl-4-benzyloxy-3-hydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

: 65-85-0,8013-63-6
benzoic acid

: 154815-47-1
(3S,4R,5R)-3-benzoyloxy-1-benzyl-4-benzyloxy-5-methoxymethoxymethyl-2-pyrrolidinone

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 14h; Ambient temperature;
DOI:10.1248/cpb.41.1717

Reference yield:

: 127298-78-6
(3R,4R,5R)-1-benzyl-4-benzyloxy-3-hydroxy-5-(methoxymethoxy)methyl-2-pyrrolidinone

: 113200-94-5
(2R,3R,4R)-N-benzyl-2-<(1S)-1-benzyloxy-4-hydroxybutyl>-3,4-bis(benzyloxy)pyrrolidine

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 14 h / Ambient temperature

2: 93 percent / 2M aq. NaOH / methanol / 0.5 h / Ambient temperature

3: 1.) NaH / 1.) THF, DMF, RT, 30 min, 2.) THF, DMF, RT, 3 h

4: 82 percent / a) borane-dimethyl sulfide complex, b) 10percent aq. HCl / a) THF, 70 deg C, 1 h, b) THF, MeOH, 70 deg C, 1 h

5: DMSO, oxalyl chloride / CH₂Cl₂ / a) -20 deg C,

6: 30 percent / tetrahydrofuran / 1 h / -78 °C

7: 1.) NaH / 1.) THF, DMF, RT, 30 min, 2.) THF, DMF, RT, 3 h

8: 1.) borane-THF complex, 2.) 3N aq. NaOH, 30percent H₂O₂ / 1.) THF, 40 deg C, 45 min, 2.) THF, 60 deg C, 30 min

With hydrogenchloride; sodium hydroxide; borane-THF; oxalyl dichloride; dimethylsulfide borane complex; dihydrogen peroxide; sodium hydride; dimethyl sulfoxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1248/cpb.41.1717