1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylic acid

Base Information

Chemical Name:1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylic acid
CAS No.:1612148-54-5
Molecular Formula:C₂₇H₂₅ClN₄O₅
Molecular Weight:520.972
Hs Code.:

Synonyms:1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylic acid

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Chemical Property of 1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylic acid

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Technology Process of 1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylic acid

There total 6 articles about 1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1612148-89-6
methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylate

: 1612148-54-5
1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylic acid

Guidance literature:: methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylate; With lithium hydroxide; In 1,4-dioxane; at 20 ℃; for 16h; Inert atmosphere;

With hydrogenchloride; In water; Inert atmosphere;
DOI:10.1021/jm5003843

Reference yield: 72.0%

: 1612148-54-5
1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylic acid

Guidance literature:: With water; lithium hydroxide; In 1,4-dioxane; at 20 ℃; Inert atmosphere;

Reference yield:

: 1146757-92-7
1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid

: 1612148-54-5
1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 16 h / 20 °C / Inert atmosphere

2.1: lithium hydroxide / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; lithium hydroxide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm5003843