ethyl 7-hydroxy-1-(2'-hydroxy-4-biphenylyl)-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate

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Chemical Name:ethyl 7-hydroxy-1-(2'-hydroxy-4-biphenylyl)-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate
CAS No.:1272672-31-7
Molecular Formula:C₂₂H₁₈N₂O₅
Molecular Weight:390.395
Hs Code.:

Synonyms:ethyl 7-hydroxy-1-(2'-hydroxy-4-biphenylyl)-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate

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Chemical Property of ethyl 7-hydroxy-1-(2'-hydroxy-4-biphenylyl)-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate

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Technology Process of ethyl 7-hydroxy-1-(2'-hydroxy-4-biphenylyl)-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate

There total 3 articles about ethyl 7-hydroxy-1-(2'-hydroxy-4-biphenylyl)-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.281%

: 1272673-98-9
ethyl 1-(4-bromophenyl)-7-hydroxy-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate

: 89466-08-0
2-hydroxyphenyl boronic acid

: 1272672-31-7
ethyl 7-hydroxy-1-(2'-hydroxy-4-biphenylyl)-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate

Guidance literature:: With potassium phosphate; tris-(o-tolyl)phosphine; palladium diacetate; In ethanol; water; at 100 ℃; for 0.25h; microwave reactor;

Reference yield:

: 1272673-97-8
ethyl 1-(4-bromophenyl)-3-{[3-(ethyloxy)-3-oxopropanoyl]amino}-1H-pyrrole-2-carboxylate

: 1272672-31-7
ethyl 7-hydroxy-1-(2'-hydroxy-4-biphenylyl)-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: pH 1

2.1: potassium phosphate; tris-(o-tolyl)phosphine / palladium diacetate / ethanol; water / 0.25 h / 100 °C / microwave reactor

With potassium phosphate; sodium hydride; tris-(o-tolyl)phosphine; palladium diacetate; In ethanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 36239-09-5
ethyl chlorocarbonylacetate

: 1272672-31-7
ethyl 7-hydroxy-1-(2'-hydroxy-4-biphenylyl)-5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

2.2: pH 1

3.1: potassium phosphate; tris-(o-tolyl)phosphine / palladium diacetate / ethanol; water / 0.25 h / 100 °C / microwave reactor

With potassium phosphate; sodium hydride; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;