5-{3-[3-(3-aminopropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile monohydrochloride

Base Information

Chemical Name:5-{3-[3-(3-aminopropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile monohydrochloride
CAS No.:1258855-91-2
Molecular Formula:C₂₅H₂₉N₅O₂*ClH
Molecular Weight:467.998
Hs Code.:

Synonyms:5-{3-[3-(3-aminopropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile monohydrochloride

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Chemical Property of 5-{3-[3-(3-aminopropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile monohydrochloride

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Technology Process of 5-{3-[3-(3-aminopropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile monohydrochloride

There total 10 articles about 5-{3-[3-(3-aminopropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258855-92-3
1,1-dimethylethyl {3-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]propyl}carbamate

: 1258855-91-2
5-{3-[3-(3-aminopropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile monohydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1258855-91-2
5-{3-[3-(3-aminopropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile monohydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / 4 h / 20 °C

2: pyridine / toluene / 1.5 h / 110 °C / Inert atmosphere; Reflux

3: hydrogenchloride / dichloromethane; 1,4-dioxane; diethyl ether / 3.5 h

4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 90 °C

5: sodium hydroxide / ethanol / 2 h / 20 °C

6: triethylamine; diphenylphosphoranyl azide / toluene / 2 h / 80 °C

7: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With pyridine; hydrogenchloride; oxalyl dichloride; diphenylphosphoranyl azide; potassium carbonate; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 264264-28-0
1,1-dimethylethyl-7-{[(trifluoromethyl)sulfonyl]oxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 1258855-91-2
5-{3-[3-(3-aminopropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile monohydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.25 h / 100 °C / Inert atmosphere

2: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 4 h / 60 °C / Reflux

3: pyridine / toluene / 1.5 h / 110 °C / Inert atmosphere; Reflux

4: hydrogenchloride / dichloromethane; 1,4-dioxane; diethyl ether / 3.5 h

5: potassium carbonate / N,N-dimethyl-formamide / 4 h / 90 °C

6: sodium hydroxide / ethanol / 2 h / 20 °C

7: triethylamine; diphenylphosphoranyl azide / toluene / 2 h / 80 °C

8: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With pyridine; hydrogenchloride; diphenylphosphoranyl azide; hydroxylamine hydrochloride; sodium hydrogencarbonate; potassium carbonate; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;