Technology Process of N-{3-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]propyl}propanamide monoformate
There total 11 articles about N-{3-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]propyl}propanamide monoformate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-{3-[3-(3-aminopropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-1,2,4-oxadiazol-5-yl}-2-[(1-methylethyl)oxy]benzonitrile monohydrochloride; propionyl chloride;
With
pyridine;
In
dichloromethane;
at 20 ℃;
for 0.333333h;
formic acid;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: oxalyl dichloride / N,N-dimethyl-formamide / 4 h / 20 °C
2: pyridine / toluene / 1.5 h / 110 °C / Inert atmosphere; Reflux
3: hydrogenchloride / dichloromethane; 1,4-dioxane; diethyl ether / 3.5 h
4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 90 °C
5: sodium hydroxide / ethanol / 2 h / 20 °C
6: triethylamine; diphenylphosphoranyl azide / toluene / 2 h / 80 °C
7: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
8: pyridine / dichloromethane / 0.33 h / 20 °C
With
pyridine; hydrogenchloride; oxalyl dichloride; diphenylphosphoranyl azide; potassium carbonate; triethylamine; sodium hydroxide;
N,N-dimethyl-formamide;
In
1,4-dioxane; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 1.25 h / 100 °C / Inert atmosphere
2: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 4 h / 60 °C / Reflux
3: pyridine / toluene / 1.5 h / 110 °C / Inert atmosphere; Reflux
4: hydrogenchloride / dichloromethane; 1,4-dioxane; diethyl ether / 3.5 h
5: potassium carbonate / N,N-dimethyl-formamide / 4 h / 90 °C
6: sodium hydroxide / ethanol / 2 h / 20 °C
7: triethylamine; diphenylphosphoranyl azide / toluene / 2 h / 80 °C
8: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
9: pyridine / dichloromethane / 0.33 h / 20 °C
With
pyridine; hydrogenchloride; diphenylphosphoranyl azide; hydroxylamine hydrochloride; sodium hydrogencarbonate; potassium carbonate; triethylamine; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
