N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-7-trifluoromethyl-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide

Base Information

Chemical Name:N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-7-trifluoromethyl-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide
CAS No.:1109230-41-2
Molecular Formula:C₃₈H₄₁F₈N₃O₃
Molecular Weight:739.749
Hs Code.:

N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-7-trifluoromethyl-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide

Synonyms:N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-7-trifluoromethyl-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide

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Chemical Property of N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-7-trifluoromethyl-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide

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Technology Process of N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-7-trifluoromethyl-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide

There total 7 articles about N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-7-trifluoromethyl-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1108698-59-4
(2R,3S)-3-Amino-4-(3,5-difluorophenyl)-1-({1-[3-(trifluoromethyl)-phenyl]cyclopropyl}amino)butan-2-ol hydrochloride

: 1109230-46-7
7-Trifluoromethyl-1-oxo-2-(1-propyl butyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid

: 1109230-41-2
N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-7-trifluoromethyl-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide

Guidance literature:: With dmap; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 123-19-3
4-heptanone

: 1109230-41-2
N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-7-trifluoromethyl-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / 1,2-dichloro-ethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 15 h / 20 °C

2.1: potassium carbonate / tetrahydrofuran / 15.08 h / 5 °C / Reflux; Inert atmosphere

3.1: dmap; trifluoromethylsulfonic anhydride / dichloromethane / 15.08 h / 10 - 20 °C

4.1: water; potassium acetate; potassium iodide / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 6 h / 100 °C

5.1: dmap; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With dmap; 1-hydroxy-7-aza-benzotriazole; trifluoromethylsulfonic anhydride; water; potassium acetate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; palladium diacetate; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 771573-00-3
2-bromo-4-trifluoromethylphenethylamine

: 1109230-41-2
N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-7-trifluoromethyl-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / 1,2-dichloro-ethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 15 h / 20 °C

2.1: potassium carbonate / tetrahydrofuran / 15.08 h / 5 °C / Reflux; Inert atmosphere

3.1: dmap; trifluoromethylsulfonic anhydride / dichloromethane / 15.08 h / 10 - 20 °C

4.1: water; potassium acetate; potassium iodide / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 6 h / 100 °C

5.1: dmap; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With dmap; 1-hydroxy-7-aza-benzotriazole; trifluoromethylsulfonic anhydride; water; potassium acetate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; palladium diacetate; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;