(2R,3S)-2,3-Epoxy-N-methyl-N-(2'-phenyl-1',3'-dithiolan-2'-ylmethyl)-3-phenylpropionamide

Base Information

Chemical Name:(2R,3S)-2,3-Epoxy-N-methyl-N-(2'-phenyl-1',3'-dithiolan-2'-ylmethyl)-3-phenylpropionamide
CAS No.:173691-08-2
Molecular Formula:C₂₁H₂₃NO₂S₂
Molecular Weight:385.551
Hs Code.:

Synonyms:(2R,3S)-2,3-Epoxy-N-methyl-N-(2'-phenyl-1',3'-dithiolan-2'-ylmethyl)-3-phenylpropionamide

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Chemical Property of (2R,3S)-2,3-Epoxy-N-methyl-N-(2'-phenyl-1',3'-dithiolan-2'-ylmethyl)-3-phenylpropionamide

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Technology Process of (2R,3S)-2,3-Epoxy-N-methyl-N-(2'-phenyl-1',3'-dithiolan-2'-ylmethyl)-3-phenylpropionamide

There total 5 articles about (2R,3S)-2,3-Epoxy-N-methyl-N-(2'-phenyl-1',3'-dithiolan-2'-ylmethyl)-3-phenylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68579-60-2,6589-55-5
2-(methylamino)-1-phenylethanol

: 173691-08-2
(2R,3S)-2,3-Epoxy-N-methyl-N-(2'-phenyl-1',3'-dithiolan-2'-ylmethyl)-3-phenylpropionamide

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / NaOMe / methanol / 48 h / 35 °C

2: 92 percent / p-TsOH / 5 h / Ambient temperature

3: 88 percent / KMnO₄, CuSO₄ / CH₂Cl₂ / 4 h / Ambient temperature

4: 76.8 percent / TiCl₄ / CH₂Cl₂ / 1.) -15 deg C, 10 min, 2.) r.t., 5 h

With potassium permanganate; sodium methylate; titanium tetrachloride; toluene-4-sulfonic acid; copper(II) sulfate; In methanol; dichloromethane;
DOI:10.1039/p19960000209

Reference yield:

: 190771-98-3
(2R,3S)-2,3-Dihydroxy-N-<(2'RS)-2'-hydroxy-2'-phenylethyl>-N-methylpropanamide

: 173691-08-2
(2R,3S)-2,3-Epoxy-N-methyl-N-(2'-phenyl-1',3'-dithiolan-2'-ylmethyl)-3-phenylpropionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / p-TsOH / 5 h / Ambient temperature

2: 88 percent / KMnO₄, CuSO₄ / CH₂Cl₂ / 4 h / Ambient temperature

3: 76.8 percent / TiCl₄ / CH₂Cl₂ / 1.) -15 deg C, 10 min, 2.) r.t., 5 h

With potassium permanganate; titanium tetrachloride; toluene-4-sulfonic acid; copper(II) sulfate; In dichloromethane;
DOI:10.1039/p19960000209

Reference yield:

: (4R,5S)--N-methylcarbamoyl>-2,2-dimethyl-5-phenyl-1,3-dioxolane

: 173691-08-2
(2R,3S)-2,3-Epoxy-N-methyl-N-(2'-phenyl-1',3'-dithiolan-2'-ylmethyl)-3-phenylpropionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / KMnO₄, CuSO₄ / CH₂Cl₂ / 4 h / Ambient temperature

2: 76.8 percent / TiCl₄ / CH₂Cl₂ / 1.) -15 deg C, 10 min, 2.) r.t., 5 h

With potassium permanganate; titanium tetrachloride; copper(II) sulfate; In dichloromethane;
DOI:10.1039/p19960000209