1-{2-[2-(2-oxopiperidin-1-yl)phenyl]ethyl}azetidin-3-yl methanesulfonate

Base Information

Chemical Name:1-{2-[2-(2-oxopiperidin-1-yl)phenyl]ethyl}azetidin-3-yl methanesulfonate
CAS No.:1430092-16-2
Molecular Formula:C₁₇H₂₄N₂O₄S
Molecular Weight:352.455
Hs Code.:

Synonyms:1-{2-[2-(2-oxopiperidin-1-yl)phenyl]ethyl}azetidin-3-yl methanesulfonate

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Chemical Property of 1-{2-[2-(2-oxopiperidin-1-yl)phenyl]ethyl}azetidin-3-yl methanesulfonate

Chemical Property:

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Technology Process of 1-{2-[2-(2-oxopiperidin-1-yl)phenyl]ethyl}azetidin-3-yl methanesulfonate

There total 6 articles about 1-{2-[2-(2-oxopiperidin-1-yl)phenyl]ethyl}azetidin-3-yl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1430092-15-1
1-{2-[2-(3-hydroxyazetidin-1-yl)ethyl]phenyl}piperidin-2-one

: 124-63-0
methanesulfonyl chloride

: 1430092-16-2
1-{2-[2-(2-oxopiperidin-1-yl)phenyl]ethyl}azetidin-3-yl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 5339-85-5
2-aminophenethyl alcohol

: 1430092-16-2
1-{2-[2-(2-oxopiperidin-1-yl)phenyl]ethyl}azetidin-3-yl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / -5 - 0 °C

2.1: potassium tert-butylate / tetrahydrofuran / -5 - 20 °C

3.1: Dess-Martin periodane / dichloromethane / 20 °C

4.1: methanol / 0.5 h / 20 °C

4.2: 20 °C

5.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With potassium tert-butylate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 4509-90-4
5-bromovaleroyl chloride

: 1430092-16-2
1-{2-[2-(2-oxopiperidin-1-yl)phenyl]ethyl}azetidin-3-yl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / -5 - 0 °C

2.1: potassium tert-butylate / tetrahydrofuran / -5 - 20 °C

3.1: Dess-Martin periodane / dichloromethane / 20 °C

4.1: methanol / 0.5 h / 20 °C

4.2: 20 °C

5.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With potassium tert-butylate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; methanol; dichloromethane;