2-hydroxy-N-((S)-1-phenylhexan-2-yl)pentadecanamide

Base Information

Chemical Name:2-hydroxy-N-((S)-1-phenylhexan-2-yl)pentadecanamide
CAS No.:951035-65-7
Molecular Formula:C₂₇H₄₇NO₂
Molecular Weight:417.676
Hs Code.:

Synonyms:2-hydroxy-N-((S)-1-phenylhexan-2-yl)pentadecanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-hydroxy-N-((S)-1-phenylhexan-2-yl)pentadecanamide

Chemical Property:

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Technology Process of 2-hydroxy-N-((S)-1-phenylhexan-2-yl)pentadecanamide

There total 5 articles about 2-hydroxy-N-((S)-1-phenylhexan-2-yl)pentadecanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 2507-54-2
2-hydroxypentadecanoic acid

: 87982-85-2
(S)-(+)-1-Phenylhexan-2-ylamine

: 951035-65-7
2-hydroxy-N-((S)-1-phenylhexan-2-yl)pentadecanamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm0613673

Reference yield:

: 951035-64-6
(R,Z)-tert-butyl 1-phenylhex-3-en-2-ylcarbamate

: 951035-65-7
2-hydroxy-N-((S)-1-phenylhexan-2-yl)pentadecanamide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethanol / 20 °C

2: HCl / diethyl ether

3: 89 percent / Et₃N; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; 1-hydroxybenzotriazole / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jm0613673

Reference yield:

: 106454-69-7
N-tert-butoxycarbonyl-D-Phenylalaninol

: 951035-65-7
2-hydroxy-N-((S)-1-phenylhexan-2-yl)pentadecanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: aq. NaBr; NaOCl; NaHCO₃ / 2,2,6,6-tetramethylpiperidine-1-yloxy free radical / toluene; ethyl acetate / -5 - 0 °C

2.1: potassium bis(trimethylsilyl)amide / toluene / 0.08 h / 0 °C

2.2: 75 percent / toluene / -78 - 20 °C

3.1: H₂ / Pd/C / ethanol / 20 °C

4.1: HCl / diethyl ether

5.1: 89 percent / Et₃N; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; 1-hydroxybenzotriazole / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; sodium hypochlorite; hydrogen; potassium hexamethylsilazane; sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; sodium bromide; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane; ethyl acetate; toluene; 2.2: Wittig reaction;
DOI:10.1021/jm0613673