((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)amino]-4-methylpentyl}thiazole-4-carbonyl)(S)-phenylaniline trifluoroacetic acid salt

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Chemical Name:((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)amino]-4-methylpentyl}thiazole-4-carbonyl)(S)-phenylaniline trifluoroacetic acid salt
CAS No.:1207472-60-3
Molecular Formula:C₂HF₃O₂*C₃₃H₄₉N₅O₅S
Molecular Weight:741.873
Hs Code.:

Synonyms:((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)amino]-4-methylpentyl}thiazole-4-carbonyl)(S)-phenylaniline trifluoroacetic acid salt

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Chemical Property of ((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)amino]-4-methylpentyl}thiazole-4-carbonyl)(S)-phenylaniline trifluoroacetic acid salt

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Technology Process of ((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)amino]-4-methylpentyl}thiazole-4-carbonyl)(S)-phenylaniline trifluoroacetic acid salt

There total 18 articles about ((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)amino]-4-methylpentyl}thiazole-4-carbonyl)(S)-phenylaniline trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1266208-72-3
C₃₄H₅₁N₅O₅S

: 76-05-1
trifluoroacetic acid

: 1207472-60-3
((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)amino]-4-methylpentyl}thiazole-4-carbonyl)(S)-phenylaniline trifluoroacetic acid salt

Guidance literature:: C₃₄H₅₁N₅O₅S; With sodium hydroxide; In 1,4-dioxane; at 0 ℃;

trifluoroacetic acid; In water; pH=2;
DOI:10.1002/ejoc.200900999

Reference yield:

: 1174764-17-0
ethyl (R)-2-{3-[(N-benzyloxycarbonyl-(S)-isoleucyl)methylamino]-4-methylpentyl}thiazole-4-carboxylate

: 1207472-60-3
((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)amino]-4-methylpentyl}thiazole-4-carbonyl)(S)-phenylaniline trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen bromide / acetic acid / 0 °C

2.1: sodium hydrogencarbonate / water

2.2: -20 - 20 °C

3.1: sodium hydroxide / 1,4-dioxane / 0 °C

3.2: pH 2

4.1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h

5.1: 4-methyl-morpholine / tetrahydrofuran / -20 - 20 °C

6.1: hydrogen bromide / acetic acid

7.1: methanol / 3 h / 20 °C

8.1: sodium hydroxide / 1,4-dioxane / 0 °C

8.2: pH 2

With 4-methyl-morpholine; hydrogen bromide; sodium hydrogencarbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetic acid;
DOI:10.1002/ejoc.200900999

Reference yield:

: 1053805-75-6
(R)-ethyl 2-(3-((tert-butoxycarbonyl)(methyl)amino)-4-methylpentyl)thiazole-4-carboxylate

: 1207472-60-3
((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)amino]-4-methylpentyl}thiazole-4-carbonyl)(S)-phenylaniline trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogenchloride / 1,4-dioxane / 0 °C

2.1: 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / -10 - 20 °C

3.1: hydrogen bromide / acetic acid / 0 °C

4.1: sodium hydrogencarbonate / water

4.2: -20 - 20 °C

5.1: sodium hydroxide / 1,4-dioxane / 0 °C

5.2: pH 2

6.1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h

7.1: 4-methyl-morpholine / tetrahydrofuran / -20 - 20 °C

8.1: hydrogen bromide / acetic acid

9.1: methanol / 3 h / 20 °C

10.1: sodium hydroxide / 1,4-dioxane / 0 °C

10.2: pH 2

With 4-methyl-morpholine; hydrogenchloride; hydrogen bromide; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid;
DOI:10.1002/ejoc.200900999