1266208-72-3

Upstream product

• 28697-07-6 (R)-1-((benzyloxy)carbonyl)piperidine-2-carboxylic acid 
• 79069-51-5 (S)-N-tert-butoxycarbonylvalinal 
• 58561-04-9 N-tert-butoxycarbonyl-L-valine methyl ester 
• 1266207-88-8 C₄₁H₅₅N₅O₇S 
• 1174764-22-7 (R)-2-{3-[(N-benzyloxycarbonyl-(R)-pipecolyl-(S)-isoleucyl)methylamino]-4-methylpentyl}thiazole-4-carboxylic acid 
• 1174764-21-6 ethyl (R)-2-{3-[(N-benzyloxycarbonyl-(R)-pipecolyl-(S)-isoleucyl)methylamino]-4-methylpentyl}thiazole-4-carboxylate 
• 1207472-50-1 (4S,2E)-4-(tert-butoxycarbonylamino)-5-methyl-2-hexenenitrile 
• 50-00-0 formaldehyd 
• 1174764-16-9 (4R)-4-[(tert-butoxycarbonyl)methylamino]-5-methylhexanethioamide 
• 1174764-15-8 (4R)-4-[(tert-butoxycarbonyl)methylamino]-5-methylhexanenitrile 
• 1219930-72-9 (4R)-4-(tert.-Butoxycarbonylamino)-5-methyl-hexanenitrile 
• 1174764-17-0 ethyl (R)-2-{3-[(N-benzyloxycarbonyl-(S)-isoleucyl)methylamino]-4-methylpentyl}thiazole-4-carboxylate 
• 1053805-75-6 (R)-ethyl 2-(3-((tert-butoxycarbonyl)(methyl)amino)-4-methylpentyl)thiazole-4-carboxylate 

Downstream Products

• 1207472-60-3 ((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)amino]-4-methylpentyl}thiazole-4-carbonyl)(S)-phenylaniline trifluoroacetic acid salt 

Relevant academic research and scientific papers

Synthesis and biological evaluation of pretubulysin and derivatives

Pretubulysin, a biosynthetic precursor of the tubulysins, shows potent biological activity in the subnanomolar range towards various tumor cell lines. Its activity is only slightly less than those of the structurally more complex tubulysins. With a straig