N-(4-acetylphenyl)-2-bromoacetamide

Base Information

• Chemical Name: N-(4-acetylphenyl)-2-bromoacetamide
• CAS No.: 29182-93-2
• Molecular Formula: C₁₀H₁₀BrNO₂
• Molecular Weight: 256.099
• DSSTox Substance ID: DTXSID701292168
• Mol file: 29182-93-2.mol

Synonyms:N-(4-acetylphenyl)-2-bromoacetamide;29182-93-2;SCHEMBL7687241;DTXSID701292168;MFCD02974382;STL570931;AKOS005172611;LS-03580

Chemical Property of N-(4-acetylphenyl)-2-bromoacetamide

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 254.98949
• Heavy Atom Count: 14
• Complexity: 222

Purity/Quality:

98%min ^*data from raw suppliers

N-(4-Acetylphenyl)-2-bromoacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)NC(=O)CBr

Technology Process of N-(4-acetylphenyl)-2-bromoacetamide

There total 4 articles about N-(4-acetylphenyl)-2-bromoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

p-aminobenzophenone (99-92-3) + 2-Bromoacetyl bromide (598-21-0) → N‐(4‐acetylphenyl)‐2‐bromoacetamide (29182-93-2)

Guidance literature:

With potassium carbonate; In dichloromethane; water; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2013.11.006

Reference yield:

p-aminobenzophenone (99-92-3) + bromoacetic acid (79-08-3) → N‐(4‐acetylphenyl)‐2‐bromoacetamide (29182-93-2)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm070564e

Reference yield:

aniline (62-53-3) → N‐(4‐acetylphenyl)‐2‐bromoacetamide (29182-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc chloride / Verseifen des Reaktionsprodukts mit Salzsaeure

2: sodium acetate; aqueous acetic acid

With sodium acetate; acetic acid; zinc(II) chloride;

upstream raw materials:

2-bromoacetyl chloride

p-aminobenzophenone

bromoacetic acid

aniline

Downstream raw materials:

N-(4-acetylphenyl)-2-[4-phenyl-5-(3,4,5-trimethoxyphenyl)-4H-[1,2,4]triazol-3-ylsulfanyl]acetamide