tert-butyl 5-(2-aminophenyl)-2,3,4,5-tetrahydro-1H-azpine-1-carboxylate

Base Information

Chemical Name:tert-butyl 5-(2-aminophenyl)-2,3,4,5-tetrahydro-1H-azpine-1-carboxylate
CAS No.:1507378-72-4
Molecular Formula:C₁₇H₂₄N₂O₂
Molecular Weight:288.39
Hs Code.:

Synonyms:tert-butyl 5-(2-aminophenyl)-2,3,4,5-tetrahydro-1H-azpine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 5-(2-aminophenyl)-2,3,4,5-tetrahydro-1H-azpine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 5-(2-aminophenyl)-2,3,4,5-tetrahydro-1H-azpine-1-carboxylate

There total 3 articles about tert-butyl 5-(2-aminophenyl)-2,3,4,5-tetrahydro-1H-azpine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1507378-70-2
tert-butyl 6-iodo-2,3,4,5-tetrahydro-1H-azepine-1-carboxylate

: 191171-55-8
2-anilineboronic acid pinacol ester

: 1507378-72-4
tert-butyl 5-(2-aminophenyl)-2,3,4,5-tetrahydro-1H-azpine-1-carboxylate

Guidance literature:: With barium hydroxide octahydrate; palladium diacetate; CyJohnPhos; Inert atmosphere;
DOI:10.1021/ol403078e

Reference yield:

: C₁₂H₂₀INO₃

: 1507378-72-4
tert-butyl 5-(2-aminophenyl)-2,3,4,5-tetrahydro-1H-azpine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / toluene / 0.17 h / 130 °C / Inert atmosphere

2: palladium diacetate; barium hydroxide octahydrate; CyJohnPhos / Inert atmosphere

With barium hydroxide octahydrate; palladium diacetate; trifluoroacetic acid; CyJohnPhos; In toluene; 2: |Suzuki Coupling;
DOI:10.1021/ol403078e

Reference yield:

: 178172-25-3
tert-butyl 2,3,4,5-tetrahydro-1H-azepine-1-carboxylate

: 1507378-72-4
tert-butyl 5-(2-aminophenyl)-2,3,4,5-tetrahydro-1H-azpine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: Iodine monochloride / dichloromethane / Inert atmosphere

2: trifluoroacetic acid / toluene / 0.17 h / 130 °C / Inert atmosphere

3: palladium diacetate; barium hydroxide octahydrate; CyJohnPhos / Inert atmosphere

With barium hydroxide octahydrate; palladium diacetate; Iodine monochloride; trifluoroacetic acid; CyJohnPhos; In dichloromethane; toluene; 3: |Suzuki Coupling;
DOI:10.1021/ol403078e