1-(4-(5-(4-(methoxycarbonyl)-3-(pyridin-2-yl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid

Base Information

Chemical Name:1-(4-(5-(4-(methoxycarbonyl)-3-(pyridin-2-yl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid
CAS No.:1236144-49-2
Molecular Formula:C₂₃H₁₉N₅O₆
Molecular Weight:461.434
Hs Code.:

Synonyms:1-(4-(5-(4-(methoxycarbonyl)-3-(pyridin-2-yl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid

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Chemical Property of 1-(4-(5-(4-(methoxycarbonyl)-3-(pyridin-2-yl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid

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Technology Process of 1-(4-(5-(4-(methoxycarbonyl)-3-(pyridin-2-yl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid

There total 7 articles about 1-(4-(5-(4-(methoxycarbonyl)-3-(pyridin-2-yl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1236144-80-1
methyl 5-(3-(4-((3-(tert-butoxycarbonyl)azetidin-1-yl)methyl)phenyl)-1,2,4-oxadiazol-5-yl)-3-(pyridin-2-yl)isoxazole-4-carboxylate

: 76-05-1
trifluoroacetic acid

: 1236144-49-2
1-(4-(5-(4-(methoxycarbonyl)-3-(pyridin-2-yl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid

Guidance literature:: methyl 5-(3-(4-((3-(tert-butoxycarbonyl)azetidin-1-yl)methyl)phenyl)-1,2,4-oxadiazol-5-yl)-3-(pyridin-2-yl)isoxazole-4-carboxylate; trifluoroacetic acid; at 20 ℃; for 1h;

With sodium hydroxide; In water; pH=~ 4;

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 1236144-49-2
1-(4-(5-(4-(methoxycarbonyl)-3-(pyridin-2-yl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 20 °C

1.2: 0 - 20 °C

2.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / tert-butyl alcohol / 20 °C / Reflux

3.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / N,N-dimethyl-formamide / 20 °C

4.1: 1 h / 20 °C

4.2: pH ~ 4

With hydroxylamine hydrochloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydrogencarbonate; triethylamine; In methanol; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 762-42-5
dimethyl acetylenedicarboxylate

: 1236144-49-2
1-(4-(5-(4-(methoxycarbonyl)-3-(pyridin-2-yl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / diethyl ether / 2.08 h / 20 °C

2.1: lithium hydroxide monohydrate; water / methanol / 1.5 h / 20 °C

2.2: pH ~ 3 - 4

3.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / N,N-dimethyl-formamide / 20 °C

4.1: 1 h / 20 °C

4.2: pH ~ 4

With lithium hydroxide monohydrate; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In methanol; diethyl ether; N,N-dimethyl-formamide;