2,3-methylenedioxy-9-(2,4-difluorobenzyloxy)-10-methoxy-1,13-cycloprotoberberine bromide

Base Information

Chemical Name:2,3-methylenedioxy-9-(2,4-difluorobenzyloxy)-10-methoxy-1,13-cycloprotoberberine bromide
CAS No.:1404305-74-3
Molecular Formula:Br*C₂₈H₂₀F₂NO₄
Molecular Weight:552.372
Hs Code.:

Synonyms:2,3-methylenedioxy-9-(2,4-difluorobenzyloxy)-10-methoxy-1,13-cycloprotoberberine bromide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,3-methylenedioxy-9-(2,4-difluorobenzyloxy)-10-methoxy-1,13-cycloprotoberberine bromide

Chemical Property:

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Technology Process of 2,3-methylenedioxy-9-(2,4-difluorobenzyloxy)-10-methoxy-1,13-cycloprotoberberine bromide

There total 5 articles about 2,3-methylenedioxy-9-(2,4-difluorobenzyloxy)-10-methoxy-1,13-cycloprotoberberine bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1404305-70-9
2,3-methylenedioxy-9-hydroxy-10-methoxy-1,13-cycloprotoberberine chloride

: 23915-07-3
1-(bromomethyl)-2,4-difluorobenzene

: 1404305-74-3
2,3-methylenedioxy-9-(2,4-difluorobenzyloxy)-10-methoxy-1,13-cycloprotoberberine bromide

Guidance literature:: With potassium hydroxide; In N,N-dimethyl-formamide; at 60 ℃; for 12h;
DOI:10.1016/j.ejmech.2013.07.026

Reference yield:

: 483-15-8
7,8-dihydroberberine

: 1404305-74-3
2,3-methylenedioxy-9-(2,4-difluorobenzyloxy)-10-methoxy-1,13-cycloprotoberberine bromide

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 5 h / 85 - 95 °C

2: hydrogenchloride / water / 1 h / 20 °C

3: 0.5 h / 195 - 210 °C / 20 - 30 Torr

4: potassium hydroxide / N,N-dimethyl-formamide / 12 h / 60 °C

With hydrogenchloride; potassium hydroxide; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2013.07.026

Reference yield:

: 1404306-19-9
2,3-methylenedioxy-9,10-dimethoxy-1,13-cycloprotoberberine chloride

: 1404305-74-3
2,3-methylenedioxy-9-(2,4-difluorobenzyloxy)-10-methoxy-1,13-cycloprotoberberine bromide

Guidance literature:: Multi-step reaction with 2 steps

1: 0.5 h / 195 - 210 °C / 20 - 30 Torr

2: potassium hydroxide / N,N-dimethyl-formamide / 12 h / 60 °C

With potassium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.07.026