(2R,3S)-N-benzoyl-O-<<2-(trimethylsilyl)ethoxy>methyl>-3-phenylisoserine

Base Information

Chemical Name:(2R,3S)-N-benzoyl-O-<<2-(trimethylsilyl)ethoxy>methyl>-3-phenylisoserine
CAS No.:99458-22-7
Molecular Formula:C₂₂H₂₉NO₅Si
Molecular Weight:415.561
Hs Code.:

Synonyms:(2R,3S)-N-benzoyl-O-<<2-(trimethylsilyl)ethoxy>methyl>-3-phenylisoserine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-N-benzoyl-O-<<2-(trimethylsilyl)ethoxy>methyl>-3-phenylisoserine

Chemical Property:

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Technology Process of (2R,3S)-N-benzoyl-O-<<2-(trimethylsilyl)ethoxy>methyl>-3-phenylisoserine

There total 6 articles about (2R,3S)-N-benzoyl-O-<<2-(trimethylsilyl)ethoxy>methyl>-3-phenylisoserine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 99458-19-2
(2R,3S)-N-benzoyl-O-<<2-(trimethylsilyl)ethoxy>methyl>-3-phenylisoserine methyl ester

: 99458-22-7
(2R,3S)-N-benzoyl-O-<<2-(trimethylsilyl)ethoxy>methyl>-3-phenylisoserine

Guidance literature:: With potassium carbonate; In methanol; water; for 15h;
DOI:10.1021/jo00351a008

Reference yield:

: 99458-15-8
Methyl (2R,3S)-(+)-2-hydroxy-3-azido-3-phenyl-propionate

: 99458-22-7
(2R,3S)-N-benzoyl-O-<<2-(trimethylsilyl)ethoxy>methyl>-3-phenylisoserine

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h

2: 1.) H₂ / 1.) 10percent Pd/C / 1.) CH₃OH, 15 h, 2.) CH₃OH, RT, 72 h

3: 96 percent / ethyldiisopropylamine / CH₂Cl₂ / 40 h

4: 92 percent / potassium carbonate / methanol; H₂O / 15 h

With dmap; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; water;
DOI:10.1021/jo00351a008

Reference yield:

: 99528-65-1
(2R,3R)-(+)-methyl 3-phenyloxiranecarboxylate

: 99458-22-7
(2R,3S)-N-benzoyl-O-<<2-(trimethylsilyl)ethoxy>methyl>-3-phenylisoserine

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / azidotrimethylsilane, zinc chloride / 48 h / 68 °C

2: 94 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h

3: 1.) H₂ / 1.) 10percent Pd/C / 1.) CH₃OH, 15 h, 2.) CH₃OH, RT, 72 h

4: 96 percent / ethyldiisopropylamine / CH₂Cl₂ / 40 h

5: 92 percent / potassium carbonate / methanol; H₂O / 15 h

With dmap; trimethylsilylazide; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; zinc(II) chloride; palladium on activated charcoal; In methanol; dichloromethane; water;
DOI:10.1021/jo00351a008