1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-sulfonyl chloride

Base Information

Chemical Name:1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-sulfonyl chloride
CAS No.:913572-12-0
Molecular Formula:C₁₈H₁₆Cl₂N₂O₃S
Molecular Weight:411.309
Hs Code.:

Synonyms:1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-sulfonyl chloride

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Chemical Property of 1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-sulfonyl chloride

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Technology Process of 1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-sulfonyl chloride

There total 6 articles about 1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913567-99-4
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazol-3-amine

: 913572-12-0
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-sulfonyl chloride

Guidance literature:: 1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazol-3-amine; With hydrogenchloride; acetic acid; sodium nitrite; In water; at -10 ℃; for 0.25h;

With sulfur dioxide; copper(l) chloride; In water; at -10 ℃;

Reference yield:

: 851205-62-4
1-(5-chloro-2-hydroxybenzyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 913572-12-0
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-sulfonyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / 18 h / Heating / reflux

2.1: sodium hydroxide; ethanol; water / 0.5 h / Heating / reflux

3.1: diphenyl phosphoryl azide; triethylamine / 22 h / 20 °C / Heating / reflux

4.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

5.1: hydrogenchloride; acetic acid; sodium nitrite / water / 0.25 h / -10 °C

5.2: -10 °C

With hydrogenchloride; sodium hydroxide; ethanol; diphenyl phosphoryl azide; water; potassium carbonate; acetic acid; triethylamine; sodium nitrite; In 1,4-dioxane; water; acetone; 3.1: Curtius Rearrangement;

Reference yield:

: 851204-79-0
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carboxylic acid

: 913572-12-0
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-sulfonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: diphenyl phosphoryl azide; triethylamine / 22 h / 20 °C / Heating / reflux

2.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

3.1: hydrogenchloride; acetic acid; sodium nitrite / water / 0.25 h / -10 °C

3.2: -10 °C

With hydrogenchloride; diphenyl phosphoryl azide; acetic acid; triethylamine; sodium nitrite; In 1,4-dioxane; water; 1.1: Curtius Rearrangement;