2-[benzyl-[2-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethyl]amino]-1-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)ethanone

Base Information

Chemical Name:2-[benzyl-[2-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethyl]amino]-1-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)ethanone
CAS No.:1414360-84-1
Molecular Formula:C₄₇H₅₈FN₅O₅S₂
Molecular Weight:856.138
Hs Code.:

2-[benzyl-[2-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethyl]amino]-1-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)ethanone

Synonyms:2-[benzyl-[2-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethyl]amino]-1-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)ethanone

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Chemical Property of 2-[benzyl-[2-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethyl]amino]-1-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)ethanone

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Technology Process of 2-[benzyl-[2-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethyl]amino]-1-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)ethanone

There total 12 articles about 2-[benzyl-[2-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethyl]amino]-1-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1179336-72-1
(2-isopropylthiazol-4-yl)-(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone

: 1414360-84-1
2-[benzyl-[2-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethyl]amino]-1-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / toluene; water / 15 - 20 °C / Industry scale

1.2: 15 - 20 °C / Industry scale

2.1: hydrogenchloride / water; 2-methyltetrahydrofuran / 2.5 h / 50 °C / Industry scale

2.2: Industry scale

3.1: hydrogen / 5% Ir/CaCO3 / ethanol / 16 h / 40 °C / 3000.3 Torr

4.1: sodium iodide; diisopropylamine / 1-methyl-pyrrolidin-2-one / 72 h / 20 °C / Inert atmosphere

With hydrogenchloride; hydrogen; sodium carbonate; diisopropylamine; sodium iodide; 5% Ir/CaCO3; In 2-methyltetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; water; toluene;

Reference yield:

: tert-butyl 7-oxa-3,10-diazaspiro[5.5]undecane-3-carboxylate hydrochloride

: 1414360-84-1
2-[benzyl-[2-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethyl]amino]-1-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)ethanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / tetrahydrofuran; 2-methyltetrahydrofuran / 1 h / 5 - 20 °C / Industry scale

2.1: hydrogenchloride; isopropyl alcohol / tert-butyl methyl ether; 2-methyltetrahydrofuran / 28 h / 20 - 40 °C / Industry scale

3.1: sodium hydroxide / water; 2-methyltetrahydrofuran / 0.33 h / 20 °C / Industry scale

4.1: sodium carbonate / toluene; water / 15 - 20 °C / Industry scale

4.2: 15 - 20 °C / Industry scale

5.1: hydrogenchloride / water; 2-methyltetrahydrofuran / 2.5 h / 50 °C / Industry scale

5.2: Industry scale

6.1: hydrogen / 5% Ir/CaCO3 / ethanol / 16 h / 40 °C / 3000.3 Torr

7.1: sodium iodide; diisopropylamine / 1-methyl-pyrrolidin-2-one / 72 h / 20 °C / Inert atmosphere

With hydrogenchloride; hydrogen; sodium carbonate; triethylamine; diisopropylamine; isopropyl alcohol; sodium iodide; sodium hydroxide; 5% Ir/CaCO3; In tetrahydrofuran; 2-methyltetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; tert-butyl methyl ether; water; toluene;

Reference yield:

: (2-isopropylthiazol-4-yl)-(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone dihydrochloride

: 1414360-84-1
2-[benzyl-[2-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethyl]amino]-1-(4-tert-butoxy-2-isopropoxy-1,3-benzothiazol-7-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water; 2-methyltetrahydrofuran / 0.33 h / 20 °C / Industry scale

2.1: sodium carbonate / toluene; water / 15 - 20 °C / Industry scale

2.2: 15 - 20 °C / Industry scale

3.1: hydrogenchloride / water; 2-methyltetrahydrofuran / 2.5 h / 50 °C / Industry scale

3.2: Industry scale

4.1: hydrogen / 5% Ir/CaCO3 / ethanol / 16 h / 40 °C / 3000.3 Torr

5.1: sodium iodide; diisopropylamine / 1-methyl-pyrrolidin-2-one / 72 h / 20 °C / Inert atmosphere

With hydrogenchloride; hydrogen; sodium carbonate; diisopropylamine; sodium iodide; sodium hydroxide; 5% Ir/CaCO3; In 2-methyltetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; water; toluene;