(2'R,3'R)-1'-acetyl-2-phenylspiro[benzo[d][1,3]oxazine-4,2'-indolin]-3'-yl nitrate

Base Information

Chemical Name:(2'R,3'R)-1'-acetyl-2-phenylspiro[benzo[d][1,3]oxazine-4,2'-indolin]-3'-yl nitrate
CAS No.:1449135-19-6
Molecular Formula:C₂₃H₁₇N₃O₅
Molecular Weight:415.405
Hs Code.:

Synonyms:(2'R,3'R)-1'-acetyl-2-phenylspiro[benzo[d][1,3]oxazine-4,2'-indolin]-3'-yl nitrate

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Chemical Property of (2'R,3'R)-1'-acetyl-2-phenylspiro[benzo[d][1,3]oxazine-4,2'-indolin]-3'-yl nitrate

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Technology Process of (2'R,3'R)-1'-acetyl-2-phenylspiro[benzo[d][1,3]oxazine-4,2'-indolin]-3'-yl nitrate

There total 5 articles about (2'R,3'R)-1'-acetyl-2-phenylspiro[benzo[d][1,3]oxazine-4,2'-indolin]-3'-yl nitrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1449134-85-3
1-((2'R,3'S)-3'-chloro-2-phenylspiro[benzo[d][1,3]oxazine-4,2'-indolin]-1'-yl)ethanone

: 1449135-19-6
(2'R,3'R)-1'-acetyl-2-phenylspiro[benzo[d][1,3]oxazine-4,2'-indolin]-3'-yl nitrate

Guidance literature:: With silver nitrate; triethylamine; In water; acetone; at 50 ℃; Inert atmosphere;
DOI:10.1021/ol4020943

Reference yield:

: 58995-87-2
N-[2-(1H-indol-2-yl)phenyl]benzamide

: 1449135-19-6
(2'R,3'R)-1'-acetyl-2-phenylspiro[benzo[d][1,3]oxazine-4,2'-indolin]-3'-yl nitrate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; dmap / tetrahydrofuran / Inert atmosphere; Reflux

2: 1,3-dichloro-5,5-diphenylhydantoin; 1,4-bis-(9-O-dihydroquinidinyl)phthalazine / chloroform / -30 °C / Inert atmosphere; Schlenk technique

3: triethylamine; silver nitrate / acetone; water / 50 °C / Inert atmosphere

With dmap; 1,4-bis-(9-O-dihydroquinidinyl)phthalazine; 1,3-dichloro-5,5-diphenylhydantoin; silver nitrate; triethylamine; In tetrahydrofuran; chloroform; water; acetone;
DOI:10.1021/ol4020943

Reference yield:

: 1449134-97-7
N-(2-(1-acetyl-1H-indol-2-yl)phenyl)benzamide

: 1449135-19-6
(2'R,3'R)-1'-acetyl-2-phenylspiro[benzo[d][1,3]oxazine-4,2'-indolin]-3'-yl nitrate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,3-dichloro-5,5-diphenylhydantoin; 1,4-bis-(9-O-dihydroquinidinyl)phthalazine / chloroform / -30 °C / Inert atmosphere; Schlenk technique

2: triethylamine; silver nitrate / acetone; water / 50 °C / Inert atmosphere

With 1,4-bis-(9-O-dihydroquinidinyl)phthalazine; 1,3-dichloro-5,5-diphenylhydantoin; silver nitrate; triethylamine; In chloroform; water; acetone;
DOI:10.1021/ol4020943