Technology Process of diethyl 2-(2-(p-tolyl)propyl)malonate
There total 3 articles about diethyl 2-(2-(p-tolyl)propyl)malonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diethyl malonate;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 ℃;
(R)-1-iodo-2-(4-methylphenyl)propane;
With
tetra-(n-butyl)ammonium iodide;
In
N,N-dimethyl-formamide; mineral oil;
at 120 ℃;
for 10h;
DOI:10.1016/j.tetasy.2012.09.008
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 10% Pd/C; hydrogen / ethanol / 6 h / 25 °C / 3102.97 Torr
2.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 10 - 25 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C
3.2: 10 h / 120 °C
With
1H-imidazole; 10% Pd/C; hydrogen; iodine; sodium hydride; triphenylphosphine;
In
ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tetasy.2012.09.008
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: osmium(VIII) oxide; methanesulfonamide; water; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III) / tert-butyl alcohol / 24 h / 0 °C
2.1: hydrogen; palladium(II) hydroxide / ethanol / 4 h / Reflux
3.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 10 - 25 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C
4.2: 10 h / 120 °C
With
1H-imidazole; osmium(VIII) oxide; methanesulfonamide; water; hydrogen; iodine; palladium(II) hydroxide; sodium hydride; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; triphenylphosphine; potassium hexacyanoferrate(III);
In
ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;
1.1: |Sharpless Dihydroxylation;
DOI:10.1016/j.tetasy.2012.09.008
