4-methanesulfonyloxy-benzoic acid 4-{2-carboxy-2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-ethyl}-benzyl ester

Base Information

Chemical Name:4-methanesulfonyloxy-benzoic acid 4-{2-carboxy-2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-ethyl}-benzyl ester
CAS No.:1055303-13-3
Molecular Formula:C₂₆H₂₅FO₇S₂
Molecular Weight:532.611
Hs Code.:

Synonyms:4-methanesulfonyloxy-benzoic acid 4-{2-carboxy-2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-ethyl}-benzyl ester

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Chemical Property of 4-methanesulfonyloxy-benzoic acid 4-{2-carboxy-2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-ethyl}-benzyl ester

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Technology Process of 4-methanesulfonyloxy-benzoic acid 4-{2-carboxy-2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-ethyl}-benzyl ester

There total 11 articles about 4-methanesulfonyloxy-benzoic acid 4-{2-carboxy-2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-ethyl}-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.8%

: 1055304-23-8
C₂₈H₂₆Cl₃FO₇S₂

: 1055303-13-3
4-methanesulfonyloxy-benzoic acid 4-{2-carboxy-2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-ethyl}-benzyl ester

Guidance literature:: With acetic acid; zinc; In dichloromethane; at 20 ℃;

Reference yield:

: 1055303-71-3
3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-chloro-propionic acid methyl ester

: 1055303-13-3
4-methanesulfonyloxy-benzoic acid 4-{2-carboxy-2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-ethyl}-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 18 h / 0 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 29 h / 0 - 20 °C

2.2: pH 2

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

4.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / 0 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

6.1: acetic acid; zinc / dichloromethane / 20 °C

With dmap; sodium hydroxide; boron trifluoride diethyl etherate; water; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 539814-10-3
4-[(methoxycarbonyl)methyl]phenyl mesylate

: 1055303-13-3
4-methanesulfonyloxy-benzoic acid 4-{2-carboxy-2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-ethyl}-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide; water / 1,4-dioxane / 0.25 h / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

3: acetic acid; zinc / dichloromethane / 20 °C

With dmap; lithium hydroxide; water; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; In 1,4-dioxane; dichloromethane;