Technology Process of 4-methanesulfonyloxy-benzoic acid 4-{2-carboxy-2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-ethyl}-benzyl ester
There total 11 articles about 4-methanesulfonyloxy-benzoic acid 4-{2-carboxy-2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-ethyl}-benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
acetic acid; zinc;
In
dichloromethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C
1.2: 18 h / 0 °C
2.1: sodium hydroxide; water / tetrahydrofuran / 29 h / 0 - 20 °C
2.2: pH 2
3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C
4.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / 0 °C
5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C
6.1: acetic acid; zinc / dichloromethane / 20 °C
With
dmap; sodium hydroxide; boron trifluoride diethyl etherate; water; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium hydroxide; water / 1,4-dioxane / 0.25 h / 20 °C
2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C
3: acetic acid; zinc / dichloromethane / 20 °C
With
dmap; lithium hydroxide; water; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc;
In
1,4-dioxane; dichloromethane;
