benzyl 4-(((3-chloropyrazin-2-yl)methyl)carbamoyl)-2-cyanopiperidine-1-carboxylate

Base Information

Chemical Name:benzyl 4-(((3-chloropyrazin-2-yl)methyl)carbamoyl)-2-cyanopiperidine-1-carboxylate
CAS No.:1620676-74-5
Molecular Formula:C₂₀H₂₀ClN₅O₃
Molecular Weight:413.863
Hs Code.:

Synonyms:benzyl 4-(((3-chloropyrazin-2-yl)methyl)carbamoyl)-2-cyanopiperidine-1-carboxylate

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Chemical Property of benzyl 4-(((3-chloropyrazin-2-yl)methyl)carbamoyl)-2-cyanopiperidine-1-carboxylate

Chemical Property:

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Technology Process of benzyl 4-(((3-chloropyrazin-2-yl)methyl)carbamoyl)-2-cyanopiperidine-1-carboxylate

There total 7 articles about benzyl 4-(((3-chloropyrazin-2-yl)methyl)carbamoyl)-2-cyanopiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 939412-86-9,867165-53-5
C-(3-chloropyrazin-2-yl)-methylamine hydrochloride salt

: 1620676-73-4
1-((benzyloxy)carbonyl)-2-cyanopiperidine-4-carboxylic acid

: 1620676-74-5
benzyl 4-(((3-chloropyrazin-2-yl)methyl)carbamoyl)-2-cyanopiperidine-1-carboxylate

Guidance literature:: With triethylamine; HATU; In dichloromethane; at 13 ℃; for 12h;

Reference yield:

: 1251844-35-5
1-benzyl 4-ethyl 2-cyanopiperidine-1,4-dicarboxylate

: 1620676-74-5
benzyl 4-(((3-chloropyrazin-2-yl)methyl)carbamoyl)-2-cyanopiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran / 13 h / 13 °C

2: triethylamine; HATU / dichloromethane / 12 h / 13 °C

With lithium hydroxide monohydrate; water; triethylamine; HATU; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1570-45-2
isonicotinic acid ethylester

: 1620676-74-5
benzyl 4-(((3-chloropyrazin-2-yl)methyl)carbamoyl)-2-cyanopiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid; dihydrogen peroxide; ferrous(II) sulfate heptahydrate / 12 h / Cooling with ice

2: platinum(IV) oxide; hydrogen; hydrogenchloride / methanol / 22 h / 2844.39 Torr

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 13 °C

4: thionyl chloride; pyridine / 12 h / 0 - 13 °C

5: lithium hydroxide monohydrate; water / tetrahydrofuran / 13 h / 13 °C

6: triethylamine; HATU / dichloromethane / 12 h / 13 °C

With pyridine; hydrogenchloride; ferrous(II) sulfate heptahydrate; platinum(IV) oxide; thionyl chloride; lithium hydroxide monohydrate; sulfuric acid; water; hydrogen; dihydrogen peroxide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; dichloromethane;