1-<<(methoxyethoxy)methyl>oxy>-1-(4-methoxyphenyl)-3-<<(4-methylphenyl)sulfonyl>oxy>propane

Base Information

Chemical Name:1-<<(methoxyethoxy)methyl>oxy>-1-(4-methoxyphenyl)-3-<<(4-methylphenyl)sulfonyl>oxy>propane
CAS No.:132777-21-0
Molecular Formula:C₂₁H₂₈O₇S
Molecular Weight:424.515
Hs Code.:

Synonyms:1-<<(methoxyethoxy)methyl>oxy>-1-(4-methoxyphenyl)-3-<<(4-methylphenyl)sulfonyl>oxy>propane

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Chemical Property of 1-<<(methoxyethoxy)methyl>oxy>-1-(4-methoxyphenyl)-3-<<(4-methylphenyl)sulfonyl>oxy>propane

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Technology Process of 1-<<(methoxyethoxy)methyl>oxy>-1-(4-methoxyphenyl)-3-<<(4-methylphenyl)sulfonyl>oxy>propane

There total 7 articles about 1-<<(methoxyethoxy)methyl>oxy>-1-(4-methoxyphenyl)-3-<<(4-methylphenyl)sulfonyl>oxy>propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 132777-38-9
1-(4-hydroxyphenyl)-1-<<(methoxyethoxy)methyl>oxy>-3-<<(4-methylphenyl)sulfonyl>oxy>propane

: 74-88-4
methyl iodide

: 132777-21-0
1-<<(methoxyethoxy)methyl>oxy>-1-(4-methoxyphenyl)-3-<<(4-methylphenyl)sulfonyl>oxy>propane

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 2.5h;
DOI:10.1021/jo00008a049

Reference yield:

: 120743-99-9
p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

: 132777-21-0
1-<<(methoxyethoxy)methyl>oxy>-1-(4-methoxyphenyl)-3-<<(4-methylphenyl)sulfonyl>oxy>propane

Guidance literature:: Multi-step reaction with 6 steps

1: 1) n-BuLi / 1) THF, -76 deg C, 10 min, 2) THF, 1 h

2: 90 percent / diisopropylethyl amine / CH₂Cl₂ / 3.5 h / 23 °C

3: 92 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

4: 97 percent / pyridine / a) 0 deg C, 15 min, b) 20 min

5: 98 percent / (n-Bu)4NF / tetrahydrofuran / 0.33 h / 23 °C

6: 87 percent / NaH / tetrahydrofuran / 2.5 h

With pyridine; lithium aluminium tetrahydride; n-butyllithium; tetrabutyl ammonium fluoride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00008a049

Reference yield:

: 132777-16-3
tert-butyl 3-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-3-hydroxypropanoate

: 132777-21-0
1-<<(methoxyethoxy)methyl>oxy>-1-(4-methoxyphenyl)-3-<<(4-methylphenyl)sulfonyl>oxy>propane

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / diisopropylethyl amine / CH₂Cl₂ / 3.5 h / 23 °C

2: 92 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

3: 97 percent / pyridine / a) 0 deg C, 15 min, b) 20 min

4: 98 percent / (n-Bu)4NF / tetrahydrofuran / 0.33 h / 23 °C

5: 87 percent / NaH / tetrahydrofuran / 2.5 h

With pyridine; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00008a049