oxalic acid 3-benzyloxycarbonylamino-3-tert-butoxycarbonyl-1,1-bis-trifluoromethyl-propyl ester phenyl ester

Base Information

Chemical Name:oxalic acid 3-benzyloxycarbonylamino-3-tert-butoxycarbonyl-1,1-bis-trifluoromethyl-propyl ester phenyl ester
CAS No.:1053719-24-6
Molecular Formula:C₂₆H₂₅F₆NO₈
Molecular Weight:593.477
Hs Code.:

oxalic acid 3-benzyloxycarbonylamino-3-<i>tert</i>-butoxycarbonyl-1,1-bis-trifluoromethyl-propyl ester phenyl ester

Synonyms:oxalic acid 3-benzyloxycarbonylamino-3-tert-butoxycarbonyl-1,1-bis-trifluoromethyl-propyl ester phenyl ester

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Chemical Property of oxalic acid 3-benzyloxycarbonylamino-3-tert-butoxycarbonyl-1,1-bis-trifluoromethyl-propyl ester phenyl ester

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Technology Process of oxalic acid 3-benzyloxycarbonylamino-3-tert-butoxycarbonyl-1,1-bis-trifluoromethyl-propyl ester phenyl ester

There total 4 articles about oxalic acid 3-benzyloxycarbonylamino-3-tert-butoxycarbonyl-1,1-bis-trifluoromethyl-propyl ester phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51719-70-1
phenyl oxalyl chloride

: 478548-20-8
tert-butyl (2S)-2-[[(benzyloxy)carbonyl]amino]-5,5,5-trifluoro-4-hydroxy-4-(trifluoromethyl)pentanoate

: 1053719-24-6
oxalic acid 3-benzyloxycarbonylamino-3-tert-butoxycarbonyl-1,1-bis-trifluoromethyl-propyl ester phenyl ester

Guidance literature:: With pyridine; In toluene; at 20 ℃; for 3h;
DOI:10.1021/ol026922j

Reference yield:

: 1145-80-8
N-(benzyloxycarbonyl)-L-serine

: 1053719-24-6
oxalic acid 3-benzyloxycarbonylamino-3-tert-butoxycarbonyl-1,1-bis-trifluoromethyl-propyl ester phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; benzyltriethylammonium chloride / acetonitrile / 5 h / 20 °C

1.2: 81 percent / acetonitrile / 45 - 50 °C

2.1: 85 percent / (PhO)3PMeI / dimethylformamide / 3.5 h / 20 °C

3.1: zinc; 1,2-dibromoethane; trimethylsilyl chloride / dimethylformamide

3.2: dimethylformamide

4.1: pyridine / toluene / 3 h / 20 °C

With pyridine; chloro-trimethyl-silane; N-benzyl-N,N,N-triethylammonium chloride; methyltriphenoxyphosphonium iodide; potassium carbonate; ethylene dibromide; zinc; In N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ol026922j

Reference yield:

: 59859-77-7
2-benzyloxycarbonylamino-3-hydroxy-propionic acid tert-butyl ester

: 1053719-24-6
oxalic acid 3-benzyloxycarbonylamino-3-tert-butoxycarbonyl-1,1-bis-trifluoromethyl-propyl ester phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 85 percent / (PhO)3PMeI / dimethylformamide / 3.5 h / 20 °C

2.1: zinc; 1,2-dibromoethane; trimethylsilyl chloride / dimethylformamide

2.2: dimethylformamide

3.1: pyridine / toluene / 3 h / 20 °C

With pyridine; chloro-trimethyl-silane; methyltriphenoxyphosphonium iodide; ethylene dibromide; zinc; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol026922j