cis-syn-2-benzyl-11,11-dimethyl-2-azatricyclo<6.4.0.0^1,6>dodecane-3,9-dione

Base Information

• Chemical Name: cis-syn-2-benzyl-11,11-dimethyl-2-azatricyclo<6.4.0.0^1,6>dodecane-3,9-dione
• CAS No.: 145801-90-7
• Molecular Formula: C₂₀H₂₅NO₂
• Molecular Weight: 311.424
• Mol file: 145801-90-7.mol

Synonyms:cis-syn-2-benzyl-11,11-dimethyl-2-azatricyclo<6.4.0.0^1,6>dodecane-3,9-dione

Chemical Property of cis-syn-2-benzyl-11,11-dimethyl-2-azatricyclo<6.4.0.0^1,6>dodecane-3,9-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-syn-2-benzyl-11,11-dimethyl-2-azatricyclo<6.4.0.0^1,6>dodecane-3,9-dione

There total 5 articles about cis-syn-2-benzyl-11,11-dimethyl-2-azatricyclo<6.4.0.0^1,6>dodecane-3,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-benzyl-N-(5,5-dimethyl-3-oxocyclohex-1-enyl)pent-4-enamide (145801-84-9) → cis-syn-2-benzyl-11,11-dimethyl-2-azatricyclo<6.4.0.01,6>dodecane-3,9-dione (145801-90-7)

Guidance literature:

In acetonitrile; Ambient temperature; Irradiation;

DOI:10.1016/S0040-4039(00)60184-3

Reference yield:

pent-4-enoyl chloride (39716-58-0) → cis-syn-2-benzyl-11,11-dimethyl-2-azatricyclo<6.4.0.01,6>dodecane-3,9-dione (145801-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / NaHMDS / tetrahydrofuran / -78 - 20 °C

2: 87 percent / acetonitrile / Irradiation

With sodium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;

Reference yield:

5,5-dimethyl-3-benzylamino-2-cyclohexen-1-one (889-31-6) → cis-syn-2-benzyl-11,11-dimethyl-2-azatricyclo<6.4.0.01,6>dodecane-3,9-dione (145801-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / NaHMDS / tetrahydrofuran / -78 - 20 °C

2: 87 percent / acetonitrile / Irradiation

With sodium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;

upstream raw materials:

N-benzyl-N-(5,5-dimethyl-3-oxocyclohex-1-enyl)pent-4-enamide

pent-4-enoyl chloride

dimedone

5,5-dimethyl-3-benzylamino-2-cyclohexen-1-one

Downstream raw materials:

1-benzyl-9,9-dimethyl-4,5,6,8,9,10-hexahydrocyclooctapyridine-2,7(1H,3H)-dione