1-((2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-((2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:163760-03-0
Molecular Formula:C₁₇H₂₈N₂O₉
Molecular Weight:404.417
Hs Code.:

Synonyms:1-((2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-((2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-((2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

There total 1 articles about 1-((2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72593-77-2,92450-98-1
3,6,9-trioxadecyl bromide

: 163760-03-0
1-((2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / NaH / tetrahydrofuran / 40 - 70 °C

2: H₂ / 5percent Pd/C / tetrahydrofuran / Ambient temperature

3: 30percent NaOMe / methanol / Ambient temperature; pH 11

4: 71 percent / H₂, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr

With hydrogen; sodium methylate; sodium acetate; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1002/hlca.19950780219

Reference yield:

: 163760-03-0
1-((2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

: 163759-84-0,168611-21-0,168611-22-1
Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 5 h / Ambient temperature

2: 72 percent / diisopropylammonium-tetrazolide / CH₂Cl₂ / Ambient temperature

With pyridine; N,N-diisopropylamine tetrazolide; In dichloromethane;
DOI:10.1002/hlca.19950780219

Reference yield:

: 163760-03-0
1-((2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

: Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-5-(5-methyl-2-oxo-4-[1,2,4]triazol-1-yl-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 5 h / Ambient temperature

2: 72 percent / diisopropylammonium-tetrazolide / CH₂Cl₂ / Ambient temperature

3: 98 percent / Et₃N, POCl₃ / acetonitrile / 16 h / Ambient temperature

With pyridine; N,N-diisopropylamine tetrazolide; triethylamine; trichlorophosphate; In dichloromethane; acetonitrile;
DOI:10.1002/hlca.19950780219