Diethylene Glycol 2-Bromoethyl Methyl Ether

Base Information

• Chemical Name: Diethylene Glycol 2-Bromoethyl Methyl Ether
• CAS No.: 72593-77-2
• Molecular Formula: C7H15BrO3
• Molecular Weight: 227.098
• Hs Code.: 29091990
• Mol file: 72593-77-2.mol

Synonyms:1-[2-(2-bromoethoxy)ethoxy]-2-methoxyethane;

Chemical Property of Diethylene Glycol 2-Bromoethyl Methyl Ether

Chemical Property:

• Vapor Pressure: 0.044mmHg at 25°C
• Refractive Index: n/D1.461
• Boiling Point: 245.798oC at 760 mmHg
• Flash Point: 96.375oC
• PSA: 27.69000
• Density: 1.288g/cm3
• LogP: 1.06090
• Storage Temp.: <0°C

Purity/Quality:

98% ^*data from raw suppliers

1-Bromo-2-[2-(2-methoxyethoxy)ethoxy]ethane ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Description: m-PEG3-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

Technology Process of Diethylene Glycol 2-Bromoethyl Methyl Ether

There total 7 articles about Diethylene Glycol 2-Bromoethyl Methyl Ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate (62921-74-8,518012-62-9,58320-73-3) → 3,6,9-trioxadecyl bromide (72593-77-2,92450-98-1)

Guidance literature:

With lithium bromide; In N,N-dimethyl-formamide; Ambient temperature;

Reference yield: 84.0%

triethylene glucol monomethyl ether (112-35-6,95507-80-5) → 3,6,9-trioxadecyl bromide (72593-77-2,92450-98-1)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 ℃; for 5h; Inert atmosphere;

DOI:10.1039/c3gc42311e

Reference yield: 67.0%

Triethylene glycol dimethyl ether (112-49-2) → 3,6,9-trioxadecyl bromide (72593-77-2,92450-98-1)

Guidance literature:

With bromine; triphenylphosphine; In diethyl ether; at 20 ℃; for 5h;

DOI:10.1021/ol048543r

upstream raw materials:

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate

triethylene glucol monomethyl ether

Triethylene glycol dimethyl ether

diethyl ether

Downstream raw materials:

1-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-octane

Butyl-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethyl}-amine

{4-[2-(2-Methoxy-ethoxy)-ethoxy]-but-1-ynyl}-benzene

1-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethylsulfanyl}-dodecane

Refernces

• 1、 Laguerre, Aurélien,Chang, Yi,Pirrotta, Marc,Desbois, Nicolas,Gros, Claude P.,Lesniewska, Eric,Monchaud, David. "Surface-promoted aggregation of amphiphilic quadruplex ligands drives their selectivity for alternative DNA structures". . p. 7034 - 7039. Retrieved 2015.
• 2、 -. "triAZOLOtriAZINE DERIVATIVES AS A2A RECEPTOR ANTAGONISTS". . . Retrieved 2020/01/24.
• 3、 De Roo, Jonathan,Zhou, Zimu,Wang, Jiaying,Deblock, Loren,Crosby, Alfred J.,Owen, Jonathan S.,Nonnenmann, Stephen S.. "Synthesis of Phosphonic Acid Ligands for Nanocrystal Surface Functionalization and Solution Processed Memristors". . p. 8034 - 8039. Retrieved 2018/10/25.