Di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-[4-({2-phenyl-5-[(tosyloxy)methyl]-1,3-dioxan-5-yl}methoxy)benzyl]-L-glutamate

Base Information

Chemical Name:Di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-[4-({2-phenyl-5-[(tosyloxy)methyl]-1,3-dioxan-5-yl}methoxy)benzyl]-L-glutamate
CAS No.:1407997-47-0
Molecular Formula:C₄₄H₅₉NO₁₂S
Molecular Weight:826.018
Hs Code.:

Synonyms:Di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-[4-({2-phenyl-5-[(tosyloxy)methyl]-1,3-dioxan-5-yl}methoxy)benzyl]-L-glutamate

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Chemical Property of Di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-[4-({2-phenyl-5-[(tosyloxy)methyl]-1,3-dioxan-5-yl}methoxy)benzyl]-L-glutamate

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Technology Process of Di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-[4-({2-phenyl-5-[(tosyloxy)methyl]-1,3-dioxan-5-yl}methoxy)benzyl]-L-glutamate

There total 4 articles about Di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-[4-({2-phenyl-5-[(tosyloxy)methyl]-1,3-dioxan-5-yl}methoxy)benzyl]-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 2209-89-4
(2-phenyl-1,3-dioxane-5,5-diyl)di(methylene) bis(4-methylbenzenesulfonate)

: 1309452-61-6
di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-(4-hydroxybenzyl)-L-glutamate

: 1407997-47-0
Di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-[4-({2-phenyl-5-[(tosyloxy)methyl]-1,3-dioxan-5-yl}methoxy)benzyl]-L-glutamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 2h; Microwave irradiation;

Reference yield:

: 5544-60-5
4-(benzyloxy)benzyl bromide

: 1407997-47-0
Di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-[4-({2-phenyl-5-[(tosyloxy)methyl]-1,3-dioxan-5-yl}methoxy)benzyl]-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 3.5 h / -70 °C

1.2: 2 h / -70 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C / Microwave irradiation

With hydrogen; potassium carbonate; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: di-tert-butyl (N-tert-butoxycarbonyl)-L-glutamate

: 1407997-47-0
Di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-[4-({2-phenyl-5-[(tosyloxy)methyl]-1,3-dioxan-5-yl}methoxy)benzyl]-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 3.5 h / -70 °C

1.2: 2 h / -70 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C / Microwave irradiation

With hydrogen; potassium carbonate; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;