5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-6-(n-butyl)-N₃-(p-methoxybenzyl)uridine

Base Information

• Chemical Name: 5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-6-(n-butyl)-N₃-(p-methoxybenzyl)uridine
• CAS No.: 1311164-91-6
• Molecular Formula: C₃₀H₄₆N₂O₇Si
• Molecular Weight: 574.79

Synonyms:5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-6-(n-butyl)-N₃-(p-methoxybenzyl)uridine

Chemical Property of 5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-6-(n-butyl)-N₃-(p-methoxybenzyl)uridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-6-(n-butyl)-N₃-(p-methoxybenzyl)uridine

There total 3 articles about 5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-6-(n-butyl)-N₃-(p-methoxybenzyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

butylboronic acid (4426-47-5) + 5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-6-iodo-N3-(p-methoxybenzyl)uridine (1311164-83-6) → 5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-6-(n-butyl)-N3-(p-methoxybenzyl)uridine (1311164-91-6)

Guidance literature:

With palladium diacetate; caesium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; for 16h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2011.03.051

Reference yield:

p-methoxybenzyl chloride (824-94-2) → 5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-6-(n-butyl)-N3-(p-methoxybenzyl)uridine (1311164-91-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 70 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 1 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 °C / Inert atmosphere

3.1: palladium diacetate; caesium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / 16 h / Inert atmosphere; Reflux

With palladium diacetate; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; n-heptane; ethylbenzene; water; acetonitrile; 3.1: Suzuki-Miyaura coupling;

DOI:10.1016/j.tet.2011.03.051

Reference yield:

5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-N3-(p-methoxybenzyl)uridine (929902-03-4) → 5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-6-(n-butyl)-N3-(p-methoxybenzyl)uridine (1311164-91-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 1 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C / Inert atmosphere

2.1: palladium diacetate; caesium carbonate; triphenylphosphine / 1,2-dimethoxyethane; water / 16 h / Inert atmosphere; Reflux

With palladium diacetate; caesium carbonate; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; n-heptane; ethylbenzene; water; 2.1: Suzuki-Miyaura coupling;

DOI:10.1016/j.tet.2011.03.051

upstream raw materials:

5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-N₃-(p-methoxybenzyl)uridine

butylboronic acid

5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-6-iodo-N₃-(p-methoxybenzyl)uridine

p-methoxybenzyl chloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1311164-91-6 5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-6-(n-butyl)-N₃-(p-methoxybenzyl)uridine

Send

Send

Metric Ton KG G Pound L ML

Send

Send