929902-03-4Relevant academic research and scientific papers
Synthesis of 6,5′-C-cyclouridine by a novel tandem radical 1,6-hydrogen transfer and cyclization reaction
Yoshimura, Yuichi,Yamazaki, Yoshiko,Wachi, Katsunori,Satoh, Shinya,Takahata, Hiroki
, p. 111 - 114 (2007)
C-Cyclonucleosides are conformational mimics and, as such, are suitable for investigating steric interactions between nucleosides and the enzymes that utilize them. To achieve the synthesis of C-cyclouridine, we developed a novel tandem radical 1,6-hydrogen transfer and cyclization of a 6-phenylselenouridine derivative, which gave 5,6-dihydro-C-cyclouridine in good yields. The synthesis of 6,5′-C-cyclouridine was accomplished by recovery of the double bond of 5,6-dihydro-C-cyclouridine and subsequent deprotection. Georg Thieme Verlag Stuttgart.
Practical synthesis of 6-aryluridines via palladium(II) acetate catalyzed Suzuki-Miyaura cross-coupling reaction
Shih, Yu-Chiao,Chien, Tun-Cheng
experimental part, p. 3915 - 3923 (2011/06/23)
Sugar-protected 6-halouridine derivatives underwent Suzuki-Miyaura cross-coupling reactions with arylboronic acids in the presence of palladium(II) acetate as a catalyst, triphenylphosphine as a ligand, and sodium carbonate as a base. This methodology is
