2-[4-(4-ethynyl-phenylethynyl)-phenyl]-4,4,5,5-tetramethyl-4,5-dihydro-imidazol-1-ol

Base Information

Chemical Name:2-[4-(4-ethynyl-phenylethynyl)-phenyl]-4,4,5,5-tetramethyl-4,5-dihydro-imidazol-1-ol
CAS No.:1027825-19-9
Molecular Formula:C₂₃H₂₂N₂O
Molecular Weight:342.44
Hs Code.:

Synonyms:2-[4-(4-ethynyl-phenylethynyl)-phenyl]-4,4,5,5-tetramethyl-4,5-dihydro-imidazol-1-ol

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Chemical Property of 2-[4-(4-ethynyl-phenylethynyl)-phenyl]-4,4,5,5-tetramethyl-4,5-dihydro-imidazol-1-ol

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Technology Process of 2-[4-(4-ethynyl-phenylethynyl)-phenyl]-4,4,5,5-tetramethyl-4,5-dihydro-imidazol-1-ol

There total 11 articles about 2-[4-(4-ethynyl-phenylethynyl)-phenyl]-4,4,5,5-tetramethyl-4,5-dihydro-imidazol-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 4,4,5,5-tetramethyl-2-[4-(4-trimethylsilanylethynyl-phenylethynyl)-phenyl]-4,5-dihydro-imidazol-1-ol

: 1027825-19-9
2-[4-(4-ethynyl-phenylethynyl)-phenyl]-4,4,5,5-tetramethyl-4,5-dihydro-imidazol-1-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.166667h;
DOI:10.1021/jo034723n

Reference yield:

: 3964-18-9
2,3-dimethyl-2,3-dinitrobutane

: 1027825-19-9
2-[4-(4-ethynyl-phenylethynyl)-phenyl]-4,4,5,5-tetramethyl-4,5-dihydro-imidazol-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / NH₄Cl; Zn / H₂O; methanol / 3 h / 0 - 20 °C

2: 78 percent / methanol / 24 h / Heating

3: 95 percent / TPP; Cu(OAc)2; Et₃N / PdCl₂ / 6 h / Heating

4: 85 percent / TBAF / tetrahydrofuran / 0.17 h

With copper diacetate; tetrabutyl ammonium fluoride; thiamine diphosphate; ammonium chloride; triethylamine; zinc; palladium dichloride; In tetrahydrofuran; methanol; water; 3: Heck-Sonogashira coupling;
DOI:10.1021/jo034723n

Reference yield:

: 52010-62-5
1-(4-Bromophenyl)-3,3-diethyltriazene

: 1027825-19-9
2-[4-(4-ethynyl-phenylethynyl)-phenyl]-4,4,5,5-tetramethyl-4,5-dihydro-imidazol-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / TPP; Cu(OAc)2; Et₃N / PdCl₂ / 6 h / Heating

2: 97 percent / MeI / 24 h / 115 °C

3: 95 percent / TPP; Cu(OAc)2; Et₃N / PdCl₂ / 6 h / Heating

4: 85 percent / TBAF / tetrahydrofuran / 0.17 h

With copper diacetate; tetrabutyl ammonium fluoride; thiamine diphosphate; triethylamine; methyl iodide; palladium dichloride; In tetrahydrofuran; 1: Heck-Sonogashira coupling / 3: Heck-Sonogashira coupling;
DOI:10.1021/jo034723n