1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-(N-methylacetamido)-benzimidazole

Base Information

Chemical Name:1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-(N-methylacetamido)-benzimidazole
CAS No.:212503-39-4
Molecular Formula:C₂₃H₁₇F₄N₃O
Molecular Weight:427.401
Hs Code.:

Synonyms:1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-(N-methylacetamido)-benzimidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-(N-methylacetamido)-benzimidazole

Chemical Property:

Purity/Quality:

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Technology Process of 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-(N-methylacetamido)-benzimidazole

There total 6 articles about 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-(N-methylacetamido)-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 212503-67-8
1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-acetamidobenzimidazole

: 74-88-4
methyl iodide

: 212503-39-4
1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-(N-methylacetamido)-benzimidazole

Guidance literature:: With sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm060103d

Reference yield:

: N-(2,6-difluorobenzoyl)-2-amino-6-nitroaniline

: 212503-39-4
1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-(N-methylacetamido)-benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / AcOH / Heating

2: 87 percent / NaH / tetrahydrofuran / 6 h

3: 90 percent / SnCl₂; AcOH; aq. HCl / 0.5 h / 20 °C

4: 95 percent / tetrahydrofuran / 5 h

5: 63 percent / NaH / tetrahydrofuran

With hydrogenchloride; sodium hydride; acetic acid; tin(ll) chloride; In tetrahydrofuran;
DOI:10.1021/jm060103d

Reference yield:

: 212503-58-7
2-(2,6-difluorophenyl)-4-nitro-benzimidazole

: 212503-39-4
1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-(N-methylacetamido)-benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / NaH / tetrahydrofuran / 6 h

2: 90 percent / SnCl₂; AcOH; aq. HCl / 0.5 h / 20 °C

3: 95 percent / tetrahydrofuran / 5 h

4: 63 percent / NaH / tetrahydrofuran

With hydrogenchloride; sodium hydride; acetic acid; tin(ll) chloride; In tetrahydrofuran;
DOI:10.1021/jm060103d