hydroxy-di-thiophen-2-yl-acetic acid (1S,2S,4R,7R)-2-{[3-(4-formyl-phenoxy)-propyl]-methyl-amino}-bicyclo[2.2.1]hept-7-yl ester

Base Information

Chemical Name:hydroxy-di-thiophen-2-yl-acetic acid (1S,2S,4R,7R)-2-{[3-(4-formyl-phenoxy)-propyl]-methyl-amino}-bicyclo[2.2.1]hept-7-yl ester
CAS No.:1092407-59-4
Molecular Formula:C₂₈H₃₁NO₅S₂
Molecular Weight:525.69
Hs Code.:

Synonyms:hydroxy-di-thiophen-2-yl-acetic acid (1S,2S,4R,7R)-2-{[3-(4-formyl-phenoxy)-propyl]-methyl-amino}-bicyclo[2.2.1]hept-7-yl ester

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Chemical Property of hydroxy-di-thiophen-2-yl-acetic acid (1S,2S,4R,7R)-2-{[3-(4-formyl-phenoxy)-propyl]-methyl-amino}-bicyclo[2.2.1]hept-7-yl ester

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Technology Process of hydroxy-di-thiophen-2-yl-acetic acid (1S,2S,4R,7R)-2-{[3-(4-formyl-phenoxy)-propyl]-methyl-amino}-bicyclo[2.2.1]hept-7-yl ester

There total 6 articles about hydroxy-di-thiophen-2-yl-acetic acid (1S,2S,4R,7R)-2-{[3-(4-formyl-phenoxy)-propyl]-methyl-amino}-bicyclo[2.2.1]hept-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1092109-99-3
hydroxy-di-thiophen-2-yl-acetic acid (1S,2S,4R,7R)-2-methylamino-bicyclo[2.2.1]hept-7-yl ester

: 17954-81-3
4-(3-bromopropoxy)benzaldehyde

: 1092407-59-4
hydroxy-di-thiophen-2-yl-acetic acid (1S,2S,4R,7R)-2-{[3-(4-formyl-phenoxy)-propyl]-methyl-amino}-bicyclo[2.2.1]hept-7-yl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 65 ℃; for 72h;

Reference yield:

: 57260-94-3
(+)-2,3-dibromobicyclo<3.2.0>heptan-6-one

: 1092407-59-4
hydroxy-di-thiophen-2-yl-acetic acid (1S,2S,4R,7R)-2-{[3-(4-formyl-phenoxy)-propyl]-methyl-amino}-bicyclo[2.2.1]hept-7-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 35 °C

1.2: 2 h / -30 - 20 °C

2.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 6.5 h / 80 °C

3.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 18 h / 20 °C / Molecular sieve

4.1: hydrogen / 20% Pd(OH)2 on carbon / ethanol / 20 h / 20 °C

5.1: sodium methylate / toluene / 70 - 140 °C

5.2: 20 °C

6.1: hydrogenchloride; water / tetrahydrofuran; 1,4-dioxane / 2 h / 50 °C

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 72 h / 65 °C

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); water; hydrogen; tri-n-butyl-tin hydride; sodium methylate; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; 20% Pd(OH)2 on carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; 1,2-dichloro-ethane; toluene; acetonitrile;

Reference yield:

: 1092109-95-9
(1R,4R,7R)-7-benzyloxy-bicyclo[2.2.1]heptan-2-one

: 1092407-59-4
hydroxy-di-thiophen-2-yl-acetic acid (1S,2S,4R,7R)-2-{[3-(4-formyl-phenoxy)-propyl]-methyl-amino}-bicyclo[2.2.1]hept-7-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 18 h / 20 °C / Molecular sieve

2.1: hydrogen / 20% Pd(OH)2 on carbon / ethanol / 20 h / 20 °C

3.1: sodium methylate / toluene / 70 - 140 °C

3.2: 20 °C

4.1: hydrogenchloride; water / tetrahydrofuran; 1,4-dioxane / 2 h / 50 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 72 h / 65 °C

With hydrogenchloride; water; hydrogen; sodium methylate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; 20% Pd(OH)2 on carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; 1,2-dichloro-ethane; toluene; acetonitrile;