17954-81-3

Usage

InChI:InChI=1/C10H11BrO2/c11-6-1-7-13-10-4-2-9(8-12)3-5-10/h2-5,8H,1,6-7H2

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 109-64-8 1,3-dibromo-propane 
• 109-70-6 1.3-chlorobromopropane 
• 37136-86-0 4-(3-Bromopropoxy)benzonitrile 
• 52191-15-8 4-(2-bromoethyloxy)benzaldehyde 
• 627-18-9 1-bromo-3-propanol 

Downstream Products

• 81121-62-2 p-(3-hydroxypropyl)-benzaldehyde 
• 5736-85-6 4-propoxybenzaldehyde 
• 877615-11-7 4-[3-(biphenyl-4-yloxy)-propoxy]-benzaldehyde 
• 1027429-00-0 2,2'-bis-[4-(3-bromo-propoxy)-phenyl]-1H,1'H-[5,5']bibenzoimidazolyl 
• 26934-35-0 4-[3-(dimethylamino)propoxy]benzaldehyde 
• 877615-32-2 3-{4-[3-(biphenyl-4-yloxy)-propoxy]-phenyl}-2-ethoxy-propionic acid ethyl ester 
• 877615-33-3 3-{4-[3-(biphenyl-4-yloxy)-propoxy]-phenyl}-2-cyclopentyloxy-propionic acid ethyl ester 

Relevant academic research and scientific papers

Design, synthesis, in silico analysis with PPAR-γ receptor and study of non-covalent interactions in unsymmetrical heterocyclic/phenyl fleximer

This work deals with the design, synthesis, in silico analysis, crystallization, and the interpretation 2-cyano-3-{4-[2-(phthalimid-nyl)-propoxy]-phenyl}-acrylic acid ethyl ester (7). Analog 7 is designed based on rosiglitazone. The quantitative analysis

β-Carboline-functionalized dithioacetal as Hg2+-selective fluorescence probe in water

A novel sensing system based on the β-carboline core has been designed and synthesized for Hg2+ detection in water. We have demonstrated that a straight forward methodology can provide rapid, sensitive and selective recognition (cross-contamination experiments) for Hg2+ over a wide pH range. The vivid fluorescence change from blue to colorless can be clearly discriminated by the naked eye. Furthermore, there is a good negative correlation between the fluorescent intensity and the concentration of Hg2+ in the range 1.0 × 10-6 M-7.0 × 10-6 M. β-Carboline as a fluorophore synthesized via this route also provides a new strategy for the design of novel fluorescence probes and fluorochromes.

Bimodal detection of carbon dioxide using fluorescent molecular aggregates

Cyano-substituted p-phenylenevinylene (R-1) aggregates exhibiting fluorescence and Raman spectroscopic responses towards CO2 are described. The aggregation-induced emission (AIE) as well as the aggregation-enhanced Raman scattering (AERS) of R-

Synthesis of novel dithiocarbamyl-containing organosilicon compounds

Aldehydes-bearing dithiocarbamate moieties were generated via highly efficient and simple method based on the one-pot reaction of amines, CS2, and 4-(bromoalkoxy)benzaldehydes with the use of K2CO3 as a catalyst under solv

Synthesis, Characterization and Biological Evaluation of Novel Triazole Linked Chromone Biheterocycle Analogs

The current work focused on the synthesis of novel chromone biheterocycle analogs followed by its characterization through physicochemical and spectral techniques like FTIR, mass and NMR spectroscopy. The basic triazole heterocycle and its analogs have di

Development of novel tetrahydroisoquinoline-hydroxamate conjugates as potent dual SERDs/HDAC inhibitors for the treatment of breast cancer

Concomitant inhibition of estrogen receptor alpha (ERα) and histone deacetylase (HDAC) signaling has been proven effective in endocrine-resistant ER+ breast cancers. Herein, a series of tetrahydroisoquinoline (THIQ)-hydroxamate conjugates were rationally

IMIDAZO [2, 1-F] [1, 2, 4] TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST

Disclosed herein is an imidazo [2, 1-f] [1, 2, 4] triazin-4-amine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof useful as a TLR7 agonist, and a pharmaceutical composition comprising the same. Also disclosed herein is a method of treating cancer using the imidazo [2, 1-f] [1, 2, 4] triazin-4-amine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof as TLR7 agonist.

A dual-acting 5-HT6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties

The complex etiology of Alzheimer's disease has initiated a quest for multi-target ligands to address the multifactorial causes of this neurodegenerative disorder. In this context, we designed dual-acting 5-HT6 receptor (5-HT6R) anta

Tuning on and off chemical- And photo-activity of exfoliated MoSe2nanosheets through morphologically selective "soft" covalent functionalization with porphyrins

The covalent functionalization of 2D transition metal dichalcogenides (TMDCs) with organic molecules exploiting the thiol conjugation approach is still a very controversial topic. We have synthesized thiolated tetraphenyl porphyrins, with and without hydr

Controlled Reduction of Nitriles by Sodium Hydride and Zinc Chloride

A new protocol for the controlled reduction of nitriles to aldehydes was developed using a combination of sodium hydride and zinc chloride. The iminyl zinc intermediates derived from aromatic nitriles could be further functionalized with allylmetal nucleophiles to afford homoallylamines. As the method allows the reduction of various aliphatic and aromatic nitriles with a concise procedure under milder reaction conditions and exhibits wide functional group compatibility, it is well suited for use in various opportunities in chemical synthesis.