ethyl 1-{6-[4-methyl-4'-(4-oxocyclohexyl)biphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Chemical Name:ethyl 1-{6-[4-methyl-4'-(4-oxocyclohexyl)biphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
CAS No.:1374341-96-4
Molecular Formula:C₃₁H₂₈F₃N₃O₃
Molecular Weight:547.577
Hs Code.:

Synonyms:ethyl 1-{6-[4-methyl-4'-(4-oxocyclohexyl)biphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Chemical Property of ethyl 1-{6-[4-methyl-4'-(4-oxocyclohexyl)biphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Technology Process of ethyl 1-{6-[4-methyl-4'-(4-oxocyclohexyl)biphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

There total 7 articles about ethyl 1-{6-[4-methyl-4'-(4-oxocyclohexyl)biphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 155098-65-0
4-(4-oxocyclohexyl)phenyl trifluoromethanesulfonate

: 1374341-95-3
ethyl 1-{6-[5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyridin-2-yl}-5-(trifluoromethyl-1H-pyrazole)-4-carboxylate

: 1374341-96-4
ethyl 1-{6-[4-methyl-4'-(4-oxocyclohexyl)biphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 15h; Inert atmosphere;

Reference yield:

: 1128268-23-4
ethyl 1-[6-(2-methoxy-5-methylphenyl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1374341-96-4
ethyl 1-{6-[4-methyl-4'-(4-oxocyclohexyl)biphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: boron tribromide / dichloromethane / 2.25 h / 0 - 20 °C

2: pyridine / dichloromethane / 0.42 h / -78 - 20 °C

3: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium acetate / acetonitrile / 15 h / 80 °C / Inert atmosphere

4: sodium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; 1,4-dioxane / 15 h / 80 °C / Inert atmosphere

With pyridine; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium acetate; boron tribromide; sodium carbonate; In 1,4-dioxane; dichloromethane; water; acetonitrile;

Reference yield:

: 1128268-25-6
ethyl 1-[6-(2-hydroxy-5-methylphenyl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1374341-96-4
ethyl 1-{6-[4-methyl-4'-(4-oxocyclohexyl)biphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 0.42 h / -78 - 20 °C

2: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium acetate / acetonitrile / 15 h / 80 °C / Inert atmosphere

3: sodium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; 1,4-dioxane / 15 h / 80 °C / Inert atmosphere

With pyridine; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium acetate; sodium carbonate; In 1,4-dioxane; dichloromethane; water; acetonitrile;