Technology Process of C18H18ClNO3
There total 7 articles about C18H18ClNO3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C18H17ClN2O;
With
water; sodium hydroxide;
In
ethanol;
at 160 ℃;
for 3h;
Molecular sieve;
With
hydrogenchloride;
In
dichloromethane; water;
pH=2;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: copper(l) iodide; sodium hydroxide / isopropyl alcohol / 90 °C / Inert atmosphere; Sealed tube
2: triethylamine / dichloromethane / 1 h / 0 °C
3: dimethyl sulfoxide / 50 °C
4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 72 h / 760.05 Torr
5: triethylamine; copper diacetate / dichloromethane / 20 °C / Molecular sieve
6: sodium hydroxide / water; ethanol / 3 h / 160 °C
With
copper(l) iodide; palladium 10% on activated carbon; hydrogen; copper diacetate; triethylamine; sodium hydroxide;
In
ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol;
DOI:10.1021/acs.jmedchem.6b01559
- Guidance literature:
-
Multi-step reaction with 6 steps
1: copper(l) iodide; sodium hydroxide / isopropyl alcohol / 90 °C / Inert atmosphere; Sealed tube
2: triethylamine / dichloromethane / 1 h / 0 °C
3: dimethyl sulfoxide / 50 °C
4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 72 h / 760.05 Torr
5: triethylamine; copper diacetate / dichloromethane / 20 °C / Molecular sieve
6: sodium hydroxide / water; ethanol / 3 h / 160 °C
With
copper(l) iodide; palladium 10% on activated carbon; hydrogen; copper diacetate; triethylamine; sodium hydroxide;
In
ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol;
DOI:10.1021/acs.jmedchem.6b01559
