(S)-3-amino-N-hydroxy-2-(7-((4-(morpholinomethyl)phenyl)ethynyl)-4-oxoquinazolin-3(4H)-yl)propanamide

Base Information

Chemical Name:(S)-3-amino-N-hydroxy-2-(7-((4-(morpholinomethyl)phenyl)ethynyl)-4-oxoquinazolin-3(4H)-yl)propanamide
CAS No.:1093191-14-0
Molecular Formula:C₂₄H₂₅N₅O₄
Molecular Weight:447.494
Hs Code.:

Synonyms:(S)-3-amino-N-hydroxy-2-(7-((4-(morpholinomethyl)phenyl)ethynyl)-4-oxoquinazolin-3(4H)-yl)propanamide

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Chemical Property of (S)-3-amino-N-hydroxy-2-(7-((4-(morpholinomethyl)phenyl)ethynyl)-4-oxoquinazolin-3(4H)-yl)propanamide

Chemical Property:

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Technology Process of (S)-3-amino-N-hydroxy-2-(7-((4-(morpholinomethyl)phenyl)ethynyl)-4-oxoquinazolin-3(4H)-yl)propanamide

There total 9 articles about (S)-3-amino-N-hydroxy-2-(7-((4-(morpholinomethyl)phenyl)ethynyl)-4-oxoquinazolin-3(4H)-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093191-13-9
(S)-methyl 3-tert-butoxycarbonylamino-2-(7-((4-(morpholinomethyl)phenyl)ethynyl)-4-oxoquinazolin-3(4H)-yl)propanoate

: 1093191-14-0
(S)-3-amino-N-hydroxy-2-(7-((4-(morpholinomethyl)phenyl)ethynyl)-4-oxoquinazolin-3(4H)-yl)propanamide

Guidance literature:: (S)-methyl 3-tert-butoxycarbonylamino-2-(7-((4-(morpholinomethyl)phenyl)ethynyl)-4-oxoquinazolin-3(4H)-yl)propanoate; With potassium hydroxide; hydroxylamine hydrochloride; In methanol; for 0.5h;

With acetic acid; In methanol; water;

With hydrogenchloride; In ethyl acetate;

Reference yield:

: 132833-51-3
4-[(4-bromophenyl)methyl]morpholine

: 1093191-14-0
(S)-3-amino-N-hydroxy-2-(7-((4-(morpholinomethyl)phenyl)ethynyl)-4-oxoquinazolin-3(4H)-yl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; di-n-propylamine / bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / N,N-dimethyl-formamide / 0.42 h / 120 °C / Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

3: copper(l) iodide; diisopropylamine / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h

4: potassium hydroxide; hydroxylamine hydrochloride / methanol / 0.5 h

With potassium hydroxide; copper(l) iodide; hydroxylamine hydrochloride; di-n-propylamine; diisopropylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1093191-11-7
(S)-methyl 2-(2-amino-4-iodobenzamido)-3-(tert-butoxycarbnylamino)propanoate

: 1093191-14-0
(S)-3-amino-N-hydroxy-2-(7-((4-(morpholinomethyl)phenyl)ethynyl)-4-oxoquinazolin-3(4H)-yl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 24 h / 120 °C

2: copper(l) iodide; diisopropylamine / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h

3: potassium hydroxide; hydroxylamine hydrochloride / methanol / 0.5 h

With potassium hydroxide; copper(l) iodide; hydroxylamine hydrochloride; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol;