(-)-3-deoxyepiclausenamide

Base Information

Chemical Name:(-)-3-deoxyepiclausenamide
CAS No.:608122-68-5
Molecular Formula:C₁₈H₁₉NO₂
Molecular Weight:281.354
Hs Code.:

Synonyms:(-)-3-deoxyepiclausenamide

Suppliers and Price of (-)-3-deoxyepiclausenamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-3-deoxyepiclausenamide

Chemical Property:

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Technology Process of (-)-3-deoxyepiclausenamide

There total 9 articles about (-)-3-deoxyepiclausenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 608122-68-5
(-)-3-deoxyepiclausenamide

Guidance literature:

Reference yield: 70.0%

: (-)-(4R,5R)-5-formyl-1-methyl-4-phenylpyrrolidin-2-one

: 100-58-3
phenylmagnesium bromide

: 608122-68-5
(-)-3-deoxyepiclausenamide

Guidance literature:: In tetrahydrofuran; at 0 ℃; enantioselective reaction;
DOI:10.1055/s-0031-1290804

Reference yield:

: C₁₆H₂₉NO₅Si

: 608122-68-5
(-)-3-deoxyepiclausenamide

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / 0 °C

2: 1,3-bis-(diphenylphosphino)propane; cesium fluoride; palladium dichloride / water; benzene / 13 h / 20 - 65 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 2587.76 Torr

4: trifluoroacetic acid / dichloromethane / 0.5 h / 0 °C

5: sodium iodide / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

6: tetrabutyl ammonium fluoride / tetrahydrofuran

7: oxalyl dichloride; triethylamine / dimethyl sulfoxide / -78 °C

8: tetrahydrofuran / 0 °C

With oxalyl dichloride; palladium 10% on activated carbon; 1,3-bis-(diphenylphosphino)propane; tetrabutyl ammonium fluoride; hydrogen; triethylamine; cesium fluoride; trifluoroacetic acid; sodium iodide; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene; 2: Suzuki-Miyaura coupling;
DOI:10.1055/s-0031-1290804