4-[2-(3-bromo-4-chloro-benzoylamino)-phenyl]-butyric acid methyl ester

Base Information

• Chemical Name: 4-[2-(3-bromo-4-chloro-benzoylamino)-phenyl]-butyric acid methyl ester
• CAS No.: 1070892-36-2
• Molecular Formula: C₁₈H₁₇BrClNO₃
• Molecular Weight: 410.695
• Mol file: 1070892-36-2.mol

Synonyms:4-[2-(3-bromo-4-chloro-benzoylamino)-phenyl]-butyric acid methyl ester

Chemical Property of 4-[2-(3-bromo-4-chloro-benzoylamino)-phenyl]-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[2-(3-bromo-4-chloro-benzoylamino)-phenyl]-butyric acid methyl ester

There total 4 articles about 4-[2-(3-bromo-4-chloro-benzoylamino)-phenyl]-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-4-chlorobenzoyl chloride (21900-34-5) + 4-(2-aminophenyl)butanoic acid methyl ester (46320-17-6) → 4-[2-(3-bromo-4-chloro-benzoylamino)-phenyl]-butyric acid methyl ester (1070892-36-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

Reference yield:

3-bromo-4-chlorobenzoic acid (42860-10-6) → 4-[2-(3-bromo-4-chloro-benzoylamino)-phenyl]-butyric acid methyl ester (1070892-36-2)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;

Reference yield:

2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one (4424-80-0) → 4-[2-(3-bromo-4-chloro-benzoylamino)-phenyl]-butyric acid methyl ester (1070892-36-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 3 h / 20 - 70 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

With sulfuric acid; N-ethyl-N,N-diisopropylamine; In dichloromethane;

upstream raw materials:

3-bromo-4-chlorobenzoyl chloride

4-(2-aminophenyl)butanoic acid methyl ester

2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one

1-tetralone oxime

Downstream raw materials:

4-{2-[(3-bromo-4-chloro-benzoyl)-methyl-amino]-phenyl}-butyric acid methyl ester

4-(2-[(3-bromo-4-chloro-benzoyl)-methyl-amino]-phenyl)-butyric acid

4-{2-[(3-bromo-4-chloro-benzoyl)-methyl-amino]-phenyl}-butyric acid tert-butyl ester

4-(2-{[4-chloro-3-(6-chloro-4-methyl-pyridin-3-yl)-benzoyl]-methyl-amino}-phenyl)-butyric acid methyl ester