2-(Hydroxymethyl)-1H-benzimidazole-4-carboxylic acid

Base Information

• Chemical Name: 2-(Hydroxymethyl)-1H-benzimidazole-4-carboxylic acid
• CAS No.: 64183-70-6
• Molecular Formula: C₉H₈N₂O₃
• Molecular Weight: 192.174
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60599627
• Nikkaji Number: J2.031.576H
• Wikidata: Q82495540
• Mol file: 64183-70-6.mol

Synonyms:64183-70-6;2-(Hydroxymethyl)-1H-benzimidazole-4-carboxylic acid;2-(hydroxymethyl)-1H-benzo[d]imidazole-4-carboxylic acid;SCHEMBL4260461;SCHEMBL9589018;DTXSID60599627;AKOS012315353;EN300-299975;2-(hydroxymethyl)-1H-1,3-benzodiazole-4-carboxylic acid

Chemical Property of 2-(Hydroxymethyl)-1H-benzimidazole-4-carboxylic acid

Chemical Property:

• PSA: 86.21000
• LogP: 0.75340
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 192.05349212
• Heavy Atom Count: 14
• Complexity: 234

Purity/Quality:

2-(hydroxymethyl)-1H-Benzimidazole-7-carboxylicacid 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C2C(=C1)NC(=N2)CO)C(=O)O

Technology Process of 2-(Hydroxymethyl)-1H-benzimidazole-4-carboxylic acid

There total 1 articles about 2-(Hydroxymethyl)-1H-benzimidazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glycolic Acid (79-14-1) + 2,3-diaminobenzoic acid (603-81-6) → 2-(hydroxymethyl)-1H-benzo[d]imidazole-4-carboxylic acid (64183-70-6)

Guidance literature:

With hydrogenchloride;

DOI:10.1016/S0960-894X(03)00706-6

Reference yield:

2-(hydroxymethyl)-1H-benzo[d]imidazole-4-carboxylic acid (64183-70-6) → 2-[(4-phenylpiperazin-1-yl)methyl]benzimidazole-4-carboxylic acid (620949-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 2 h / 80 °C

1.2: 95 percent / HCl / 0.25 h / Heating

2.1: 50 percent / triethylamine / acetonitrile / 20 h / 60 °C

With thionyl chloride; triethylamine; In acetonitrile;

DOI:10.1016/j.bmc.2004.07.023

Reference yield:

2-(hydroxymethyl)-1H-benzo[d]imidazole-4-carboxylic acid (64183-70-6) → 2-[[4-(m-chlorophenyl)piperazin-1-yl]methyl]benzimidazole-4-carboxylic acid (620950-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 2 h / 80 °C

1.2: 95 percent / HCl / 0.25 h / Heating

2.1: 56 percent / triethylamine / acetonitrile / 20 h / 60 °C

With thionyl chloride; triethylamine; In acetonitrile;

DOI:10.1016/j.bmc.2004.07.023

upstream raw materials:

glycolic Acid

2,3-diaminobenzoic acid

Downstream raw materials:

2-[[4-(1-tritylbenzimidazol-4-yl)piperazin-1-yl]methyl]benzimidazole-4-carboxylic acid

2-[(4-phenylpiperazin-1-yl)methyl]benzimidazole-4-carboxylic acid

2-[[4-(m-chlorophenyl)piperazin-1-yl]methyl]benzimidazole-4-carboxylic acid

2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]benzimidazole-4-carboxylic acid