(2R,4S)-2-Methyl-4-[2-(4-propyl-phenyl)-ethyl]-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

Base Information

Chemical Name:(2R,4S)-2-Methyl-4-[2-(4-propyl-phenyl)-ethyl]-pentanedioic acid 5-benzyl ester 1-tert-butyl ester
CAS No.:177218-77-8
Molecular Formula:C₂₈H₃₈O₄
Molecular Weight:438.607
Hs Code.:

Synonyms:(2R,4S)-2-Methyl-4-[2-(4-propyl-phenyl)-ethyl]-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

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Chemical Property of (2R,4S)-2-Methyl-4-[2-(4-propyl-phenyl)-ethyl]-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

Chemical Property:

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Technology Process of (2R,4S)-2-Methyl-4-[2-(4-propyl-phenyl)-ethyl]-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

There total 4 articles about (2R,4S)-2-Methyl-4-[2-(4-propyl-phenyl)-ethyl]-pentanedioic acid 5-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25711-53-9
4-(4-n-propylphenyl)butanoic acid

: 177218-77-8
(2R,4S)-2-Methyl-4-[2-(4-propyl-phenyl)-ethyl]-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1) (COCl)2, 2) n-BuLi / 1) CH₂Cl₂, 2) THF

2: Cl₃Ti(O-i-Pr), (i-Pr)2NEt / CH₂Cl₂ / 0 °C

3: H₂O₂, LiOH / tetrahydrofuran; H₂O

4: 1) LDA, 2) EDC, 4-DMAP / 1) HMPA, THF

With dmap; lithium hydroxide; n-butyllithium; oxalyl dichloride; titanium(IV) trichloride isopropoxide; dihydrogen peroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/0960-894X(96)00109-6

Reference yield:

: 162734-31-8
3-(4-(4-(1-n-Propyl)phenyl)butanoyl)-4(S)-phenylmethyl-2-oxazolidinone

: 177218-77-8
(2R,4S)-2-Methyl-4-[2-(4-propyl-phenyl)-ethyl]-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Cl₃Ti(O-i-Pr), (i-Pr)2NEt / CH₂Cl₂ / 0 °C

2: H₂O₂, LiOH / tetrahydrofuran; H₂O

3: 1) LDA, 2) EDC, 4-DMAP / 1) HMPA, THF

With dmap; lithium hydroxide; titanium(IV) trichloride isopropoxide; dihydrogen peroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/0960-894X(96)00109-6

Reference yield:

: 162734-33-0
(R)-4-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-6-(4-propyl-phenyl)-hexanoic acid tert-butyl ester

: 177218-77-8
(2R,4S)-2-Methyl-4-[2-(4-propyl-phenyl)-ethyl]-pentanedioic acid 5-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂O₂, LiOH / tetrahydrofuran; H₂O

2: 1) LDA, 2) EDC, 4-DMAP / 1) HMPA, THF

With dmap; lithium hydroxide; dihydrogen peroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium diisopropyl amide; In tetrahydrofuran; water;
DOI:10.1016/0960-894X(96)00109-6