(E)-4-(3-(4-chlorophenyl)-5-(cyclohex-1-en-1-yl)isoxazol-4-yl)but-3-en-2-one

Base Information

Chemical Name:(E)-4-(3-(4-chlorophenyl)-5-(cyclohex-1-en-1-yl)isoxazol-4-yl)but-3-en-2-one
CAS No.:1365162-90-8
Molecular Formula:C₁₉H₁₈ClNO₂
Molecular Weight:327.81
Hs Code.:

Synonyms:(E)-4-(3-(4-chlorophenyl)-5-(cyclohex-1-en-1-yl)isoxazol-4-yl)but-3-en-2-one

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Chemical Property of (E)-4-(3-(4-chlorophenyl)-5-(cyclohex-1-en-1-yl)isoxazol-4-yl)but-3-en-2-one

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Technology Process of (E)-4-(3-(4-chlorophenyl)-5-(cyclohex-1-en-1-yl)isoxazol-4-yl)but-3-en-2-one

There total 4 articles about (E)-4-(3-(4-chlorophenyl)-5-(cyclohex-1-en-1-yl)isoxazol-4-yl)but-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1365162-71-5
(Z)-1-(4-chlorophenyl)-3-(cyclohex-1-en-1-yl)prop-2-yn-1-one O-methyl oxime

: 78-94-4,25038-87-3
methyl vinyl ketone

: 1365162-90-8
(E)-4-(3-(4-chlorophenyl)-5-(cyclohex-1-en-1-yl)isoxazol-4-yl)but-3-en-2-one

Guidance literature:: With palladium(II) trifluoroacetate; tetrabutylammomium bromide; lithium carbonate; copper dichloride; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 2h;
DOI:10.1021/jo300090k

Reference yield:

: 101002-65-7
1-(4-chlorophenyl)-3-(cyclohex-1-en-1-yl)prop-2-yn-1-one

: 1365162-90-8
(E)-4-(3-(4-chlorophenyl)-5-(cyclohex-1-en-1-yl)isoxazol-4-yl)but-3-en-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; sodium sulfate / methanol / 20 °C

2: palladium(II) trifluoroacetate; tetrabutylammomium bromide; lithium carbonate; copper dichloride / 1-methyl-pyrrolidin-2-one / 2 h / 150 °C

With pyridine; palladium(II) trifluoroacetate; tetrabutylammomium bromide; lithium carbonate; sodium sulfate; copper dichloride; In 1-methyl-pyrrolidin-2-one; methanol; 2: Heck reaction;
DOI:10.1021/jo300090k

Reference yield:

: 931-49-7
1-ethenylcyclohexene

: 1365162-90-8
(E)-4-(3-(4-chlorophenyl)-5-(cyclohex-1-en-1-yl)isoxazol-4-yl)but-3-en-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; water; triethylamine / 20 °C / Inert atmosphere

2: pyridine; sodium sulfate / methanol / 20 °C

3: palladium(II) trifluoroacetate; tetrabutylammomium bromide; lithium carbonate; copper dichloride / 1-methyl-pyrrolidin-2-one / 2 h / 150 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium(II) trifluoroacetate; tetrabutylammomium bromide; water; lithium carbonate; sodium sulfate; triethylamine; copper dichloride; In 1-methyl-pyrrolidin-2-one; methanol; 1: Sonogashira coupling / 3: Heck reaction;
DOI:10.1021/jo300090k