(R)-4-Benzyl-3-{(2R,3S,4S)-3-hydroxy-4-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-methyl-pentanoyl}-oxazolidin-2-one

Base Information

Chemical Name:(R)-4-Benzyl-3-{(2R,3S,4S)-3-hydroxy-4-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-methyl-pentanoyl}-oxazolidin-2-one
CAS No.:252342-41-9
Molecular Formula:C₂₈H₃₅NO₇
Molecular Weight:497.588
Hs Code.:

Synonyms:(R)-4-Benzyl-3-{(2R,3S,4S)-3-hydroxy-4-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-methyl-pentanoyl}-oxazolidin-2-one

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Chemical Property of (R)-4-Benzyl-3-{(2R,3S,4S)-3-hydroxy-4-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-methyl-pentanoyl}-oxazolidin-2-one

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Technology Process of (R)-4-Benzyl-3-{(2R,3S,4S)-3-hydroxy-4-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-methyl-pentanoyl}-oxazolidin-2-one

There total 3 articles about (R)-4-Benzyl-3-{(2R,3S,4S)-3-hydroxy-4-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-methyl-pentanoyl}-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 101711-78-8,131685-53-5
(3R)-3-propionyl-4-benzyloxazolidin-2-one

: 303727-85-7
(R)-2-[(4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxinan-4-yl]propionaldehyde

: 252342-41-9
(R)-4-Benzyl-3-{(2R,3S,4S)-3-hydroxy-4-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-methyl-pentanoyl}-oxazolidin-2-one

Guidance literature:: (3R)-3-propionyl-4-benzyloxazolidin-2-one; (R)-2-[(4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxinan-4-yl]propionaldehyde; With di-n-butylboryl trifluoromethanesulfonate; triethylamine; In dichloromethane; at -78 - 0 ℃; for 1.5h;

With water; In methanol; dichloromethane; at 0 ℃; for 1h; Further stages.;
DOI:10.1021/ja0015287

Reference yield:

: 132969-62-1
(2'R,3'S,4'S,4R,5S)-3-[3'-hydroxy-5'-(4-methoxyphenyl)methoxy-2',4'-dimethylpentanoyl]-5-phenyl-4-methyl-2-oxazolidinone

: 252342-41-9
(R)-4-Benzyl-3-{(2R,3S,4S)-3-hydroxy-4-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-methyl-pentanoyl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: Me₃Al / -78 °C

2: DDQ; 4 Angstroem MS

3: LAH / tetrahydrofuran

4: Bu₂BOTf

With lithium aluminium tetrahydride; 4 Angstroem MS; di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran;
DOI:10.1021/ol9910870

Reference yield:

: 303727-84-6
(R)-N-methoxy-2-[(2S,4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxinan-4-yl]-N-methylpropionamide

: 252342-41-9
(R)-4-Benzyl-3-{(2R,3S,4S)-3-hydroxy-4-[(2S,4S,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-methyl-pentanoyl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: LAH / tetrahydrofuran

2: Bu₂BOTf

With lithium aluminium tetrahydride; di-n-butylboryl trifluoromethanesulfonate; In tetrahydrofuran;
DOI:10.1021/ol9910870