4-amino-N-ethyl-N-phenylbenzenesulfonamide

Base Information

• Chemical Name: 4-amino-N-ethyl-N-phenylbenzenesulfonamide
• CAS No.: 50497-33-1
• Molecular Formula: C14H16N2O2S
• Molecular Weight: 276.359
• Hs Code.: 2935009090
• DSSTox Substance ID: DTXSID70356804
• Wikidata: Q82136383
• ChEMBL ID: CHEMBL1447873
• Mol file: 50497-33-1.mol

Synonyms:4-amino-N-ethyl-N-phenylbenzenesulfonamide;50497-33-1;4-amino-N-ethyl-N-phenylbenzene-1-sulfonamide;Oprea1_159170;MLS000103548;SCHEMBL2603075;CHEMBL1447873;DTXSID70356804;HMS1592G15;HMS2258H21;STK027077;AKOS000200214;SMR000017362;EN300-26451;AN-329/41928088;SR-01000272395;SR-01000272395-1;Z57265644;F1673-6643

Chemical Property of 4-amino-N-ethyl-N-phenylbenzenesulfonamide

Chemical Property:

• Vapor Pressure: 2.75E-08mmHg at 25°C
• Refractive Index: 1.632
• Boiling Point: 449.9°C at 760 mmHg
• Flash Point: 225.9°C
• PSA: 71.78000
• Density: 1.28g/cm³
• LogP: 4.14600
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 276.09324893
• Heavy Atom Count: 19
• Complexity: 363

Purity/Quality:

98%min ^*data from raw suppliers

4-Amino-N-ethyl-N-phenylbenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(C1=CC=CC=C1)S(=O)(=O)C2=CC=C(C=C2)N

Technology Process of 4-amino-N-ethyl-N-phenylbenzenesulfonamide

There total 5 articles about 4-amino-N-ethyl-N-phenylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-ethyl-4-nitro-N-phenylbenzenesulfonamide (211675-98-8) → 4-amino-N-ethyl-N-phenylbenzene sulfonamide (50497-33-1)

Guidance literature:

With tin(ll) chloride; In tetrahydrofuran; ethanol; at 20 ℃;

DOI:10.1016/j.bmcl.2005.10.050

Reference yield:

N-ethyl-N-phenylamine (103-69-5) → 4-amino-N-ethyl-N-phenylbenzene sulfonamide (50497-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / TEA / 1 h / 0 °C

2: 75 percent / SnCl₂*2H₂O / tetrahydrofuran; ethanol / 20 °C

With TEA; tin(ll) chloride; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2005.10.050

Reference yield:

4-Nitrobenzenesulfonyl chloride (98-74-8) → 4-amino-N-ethyl-N-phenylbenzene sulfonamide (50497-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / TEA / 1 h / 0 °C

2: 75 percent / SnCl₂*2H₂O / tetrahydrofuran; ethanol / 20 °C

With TEA; tin(ll) chloride; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2005.10.050

upstream raw materials:

N-acetyl-sulfanilic acid-(N-ethyl-anilide)

N-ethyl-4-nitro-N-phenylbenzenesulfonamide

N-ethyl-N-phenylamine

4-Nitrobenzenesulfonyl chloride

Downstream raw materials:

[4-(Ethyl-phenyl-sulfamoyl)-phenylamino]-acetic acid

1-[4-(Ethyl-phenyl-sulfamoyl)-phenyl]-1H-pyrazole-3,4-dicarboxylic acid dimethyl ester

C₁₆H₁₇N₃O₅S

6,7,8,9-Tetrahydro-5H-carbazole-3-sulfonic acid ethyl-phenyl-amide