Pyrrolo[2,1-a]isoquinolin-3(2H)-one, 1,5,6,10b-tetrahydro-1,2-dihydroxy-, (1R,2R,10bS)- (9CI)

Base Information

• Chemical Name: Pyrrolo[2,1-a]isoquinolin-3(2H)-one, 1,5,6,10b-tetrahydro-1,2-dihydroxy-, (1R,2R,10bS)- (9CI)
• CAS No.: 524950-94-5
• Molecular Formula: C12H13NO3
• Molecular Weight: 219.23652
• Mol file: 524950-94-5.mol

Synonyms:Pyrrolo[2,1-a]isoquinolin-3(2H)-one, 1,5,6,10b-tetrahydro-1,2-dihydroxy-, (1R,2R,10bS)- (9CI)

Chemical Property of Pyrrolo[2,1-a]isoquinolin-3(2H)-one, 1,5,6,10b-tetrahydro-1,2-dihydroxy-, (1R,2R,10bS)- (9CI)

Chemical Property:

• PSA: 60.77000
• LogP: -0.21430

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrrolo[2,1-a]isoquinolin-3(2H)-one, 1,5,6,10b-tetrahydro-1,2-dihydroxy-, (1R,2R,10bS)- (9CI)

There total 23 articles about Pyrrolo[2,1-a]isoquinolin-3(2H)-one, 1,5,6,10b-tetrahydro-1,2-dihydroxy-, (1R,2R,10bS)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(7aS,10aS,10bR)-9,9-dimethyl-5,7a,10a,10b-tetrahydro-6H-8,10-dioxa-6a-azapentaleno[1,2-a]naphthalen-7-one (524950-85-4) → (1S,2S,10bR)-1,2-dihydroxy-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-3-one (524950-88-7,524950-94-5)

Guidance literature:

With methanol; acetyl chloride; at 0 - 20 ℃; for 3h;

DOI:10.1016/S0957-4166(02)00785-1

Reference yield: 90.0%

(1S,2R,10bS)-1,2-diacetoxy-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-3-one → (1S,2R,10bS)-1,2-dihydroxy-1,2,3,5,6,10bβ-hexahydropyrrolo<2,1-a>isoquinolin-3(2H)-one (164736-96-3,524950-94-5)

Guidance literature:

With methanol; acetyl chloride; at 0 - 20 ℃; for 3h;

DOI:10.1016/S0957-4166(02)00785-1

Reference yield: 88.0%

(7aS,10aS,10bS)-9,9-dimethyl-5,7a,10a,10b-tetrahydro-6H-8,10-dioxa-6a-azapentaleno[1,2-a]naphthalen-7-one (524950-84-3) → (1S,2S,10bS)-1,2-dihydroxy-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-3-one (524950-87-6,524950-94-5)

Guidance literature:

With methanol; acetyl chloride; at 0 - 20 ℃; for 3h;

DOI:10.1016/S0957-4166(02)00785-1

upstream raw materials:

phenethylamine

(3R,4R)-3,4-dihydroxy-1-(2-phenylethyl)-2,5-pyrrolidinedione

(7aS,10aS,10bS)-9,9-dimethyl-5,7a,10a,10b-tetrahydro-6H-8,10-dioxa-6a-azapentaleno[1,2-a]naphthalen-7-one

(1S,2S,10bS)-1-benzoyloxy-2-hydroxy-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-3-one

Downstream raw materials:

(1S,2S,10bS)-1,2-dihydroxy-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-3-one