Methyl -chloro-hydroxy benzenepropanoate

Base Information

• Chemical Name: Methyl -chloro-hydroxy benzenepropanoate
• CAS No.: 50485-71-7
• Molecular Formula: C10H11ClO3
• Molecular Weight: 214.649
• Hs Code.: 2918199090
• Mol file: 50485-71-7.mol

Synonyms:Methyl 2-chloro-3-hydroxy-3-phenylpropionate;Methyl -chloro-hydroxy benzenepropanoate

Chemical Property of Methyl -chloro-hydroxy benzenepropanoate

Chemical Property:

• Melting Point: 58 °C
• Boiling Point: 348.5±37.0 °C(Predicted)
• PKA: 12?+-.0.20(Predicted)
• PSA: 41.52000
• Density: 1.271±0.06 g/cm3(Predicted)
• LogP: 2.11720

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl -chloro-hydroxy benzenepropanoate

There total 17 articles about Methyl -chloro-hydroxy benzenepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

dichloroacetic acid methyl ester (116-54-1) + benzaldehyde (100-52-7) → methyl 2-chloro-3-hydroxy-3-phenylpropanoate (50485-71-7)

Guidance literature:

With chromium dichloride; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2004.05.113

Reference yield: 6.0%

benzaldehyde (100-52-7) + methyl chloroacetate (96-34-4) → methyl 3-Phenylglycidate (19190-80-8,37161-74-3,40956-18-1,41603-34-3,99528-65-1,115794-66-6,115794-67-7,115794-68-8,130607-99-7) + methyl 2-chloro-3-hydroxy-3-phenylpropanoate (50485-71-7) + methyl 2-hydroxy-3-methoxy-3-phenylpropanoate (141085-68-9) + benzyl alcohol (100-51-6,185532-71-2)

Guidance literature:

With magnesium methanolate; In methanol; at 0 ℃; for 15h;

DOI:10.1135/cccc19920119

Reference yield:

methyl erythro-2-chloro-3-chloroacetoxy-3-phenylpropanoate (120235-87-2) → methyl 2-chloro-3-phenylprop-2(Z)-enoate (14737-94-1) + cis-methyl 2,3-epoxy-3-phenylpropanoate (19190-80-8,37161-74-3,40956-18-1,41603-34-3,99528-65-1,115794-66-6,115794-67-7,115794-68-8,130607-99-7) + methyl erythro-2-chloro-3-hydroxy-3-phenylpropanoate (40956-42-1,40956-43-2,49602-00-8,49602-01-9,50485-71-7) + methyl trans-3-phenylglycidate (19190-80-8,37161-74-3,40956-18-1,41603-34-3,99528-65-1,115794-66-6,115794-67-7,115794-68-8,130607-99-7)

Guidance literature:

With triethylamine hydrochloride; triethylamine; In methanol; at 30 ℃; Rate constant;

upstream raw materials:

methyl 2,2-dichloro-3-hydroxy-3-phenylpropanoate

benzaldehyde

methyl chloroacetate

dichloroacetic acid methyl ester

Downstream raw materials:

methyl erythro-2-chloro-3-dichloroacetoxy-3-phenylpropanoate

methyl erythro-2-chloro-3-chloroacetoxy-3-phenylpropanoate

methyl erythro-2-chloro-3-trichloroacetoxy-3-phenylpropanoate

methyl 3-bromo-2-chloro-3-phenylpropanoate

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