3-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]propanol

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Chemical Name:3-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]propanol
CAS No.:1363375-27-2
Molecular Formula:C₂₃H₂₆FNO₄S
Molecular Weight:431.528
Hs Code.:

Synonyms:3-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]propanol

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Chemical Property of 3-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]propanol

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Technology Process of 3-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]propanol

There total 4 articles about 3-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1386391-07-6
1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)propoxy)ethyl)-1H-pyrrole

: 1363375-27-2
3-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]propanol

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol; at 55 ℃; for 1h;
DOI:10.1021/jm301370e

Reference yield: 40.0%

: 1363375-27-2
3-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]propanol

Guidance literature:

Reference yield:

: 1-(4-fluoro)phenyl-3-(2-hydroxyethyl)-2-methyl-5-[(4-methylsulfonyl)phenyl]-1H-pyrrole

: 1363375-27-2
3-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]propanol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; sodium hydroxide / water / 72 h / 70 °C / Inert atmosphere

2: pyridinium p-toluenesulfonate / methanol / 1 h / 55 °C

With tetrabutylammomium bromide; pyridinium p-toluenesulfonate; sodium hydroxide; In methanol; water;
DOI:10.1021/jm301370e