1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)propoxy)ethyl)-1H-pyrrole

Base Information

• Chemical Name: 1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)propoxy)ethyl)-1H-pyrrole
• CAS No.: 1386391-07-6
• Molecular Formula: C₂₈H₃₄FNO₅S
• Molecular Weight: 515.646

Synonyms:1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)propoxy)ethyl)-1H-pyrrole

Chemical Property of 1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)propoxy)ethyl)-1H-pyrrole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)propoxy)ethyl)-1H-pyrrole

There total 2 articles about 1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)propoxy)ethyl)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(tetrahydro-2H-pyran-2-yloxy)propyl bromide (33821-94-2) + 1-(4-fluoro)phenyl-3-(2-hydroxyethyl)-2-methyl-5-[(4-methylsulfonyl)phenyl]-1H-pyrrole → 1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)propoxy)ethyl)-1H-pyrrole (1386391-07-6)

Guidance literature:

With tetrabutylammomium bromide; sodium hydroxide; In water; at 70 ℃; for 72h; Inert atmosphere;

DOI:10.1021/jm301370e

Reference yield:

ethyl 2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetate (959632-81-6) → 1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)propoxy)ethyl)-1H-pyrrole (1386391-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / Inert atmosphere

2: tetrabutylammomium bromide; sodium hydroxide / water / 72 h / 70 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetrabutylammomium bromide; sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1021/jm301370e

Reference yield: 40.0%

1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)propoxy)ethyl)-1H-pyrrole (1386391-07-6) → 3-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]propanol (1363375-27-2)

Guidance literature:

With pyridinium p-toluenesulfonate; In methanol; at 55 ℃; for 1h;

DOI:10.1021/jm301370e

upstream raw materials:

ethyl 2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]acetate

3-(tetrahydro-2H-pyran-2-yloxy)propyl bromide

Downstream raw materials:

3-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]propanol

3-(2-(1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl)ethoxy)propyl methanesulfonate

3-[2-[2-(1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl)]ethoxy]propyl nitrate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1386391-07-6 1-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)-3-(2-((tetrahydro-2H-pyran-2-yloxy)propoxy)ethyl)-1H-pyrrole

Send

Send

Metric Ton KG G Pound L ML

Send

Send