dimethyl (2R)-2-(3-((4-oxo-2-thioxothiazolidin-5-yl)methyl)benzamido)pentanedioate

Base Information

Chemical Name:dimethyl (2R)-2-(3-((4-oxo-2-thioxothiazolidin-5-yl)methyl)benzamido)pentanedioate
CAS No.:1334590-93-0
Molecular Formula:C₁₈H₂₀N₂O₆S₂
Molecular Weight:424.499
Hs Code.:

Synonyms:dimethyl (2R)-2-(3-((4-oxo-2-thioxothiazolidin-5-yl)methyl)benzamido)pentanedioate

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Chemical Property of dimethyl (2R)-2-(3-((4-oxo-2-thioxothiazolidin-5-yl)methyl)benzamido)pentanedioate

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Technology Process of dimethyl (2R)-2-(3-((4-oxo-2-thioxothiazolidin-5-yl)methyl)benzamido)pentanedioate

There total 3 articles about dimethyl (2R)-2-(3-((4-oxo-2-thioxothiazolidin-5-yl)methyl)benzamido)pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1334590-76-9
dimethyl (R,Z)-2-(3-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzamido)pentanedioate

: 1334590-93-0
dimethyl (2R)-2-(3-((4-oxo-2-thioxothiazolidin-5-yl)methyl)benzamido)pentanedioate

Guidance literature:: With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; silica gel; In toluene; at 100 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.05.070

Reference yield:

: 619-21-6
m-formylphenyl benzoic acid

: 1334590-93-0
dimethyl (2R)-2-(3-((4-oxo-2-thioxothiazolidin-5-yl)methyl)benzamido)pentanedioate

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine; acetic acid / ethanol / 0.33 h / 150 °C / Microwave irradiation

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C / pH 8

3: diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; silica gel / toluene / 24 h / 100 °C / Inert atmosphere

With piperidine; 4-methyl-morpholine; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; silica gel; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide; toluene; 1: Knoevenagel condensation;
DOI:10.1016/j.ejmech.2011.05.070

Reference yield:

: 1334590-73-6
(Z)-3-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzoic acid

: 1334590-93-0
dimethyl (2R)-2-(3-((4-oxo-2-thioxothiazolidin-5-yl)methyl)benzamido)pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C / pH 8

2: diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; silica gel / toluene / 24 h / 100 °C / Inert atmosphere

With 4-methyl-morpholine; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; silica gel; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2011.05.070